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- W2155536596 abstract "Abstract: It was observed in earlier studies that when the phosphorylase a activity of rabbit colon smooth muscle was increased by anoxia or 2,4-dinitrophenol (DNP), the calcium content of the mitochondrial fraction decreased. Despite this, under basal conditions there was no significant increase in the Ca2+ content in the fraction consisting of microsomes and cytoplasm. In the present study it was therefore investigated whether mitochondrial Ca2+ released by anoxia and DNP is translocated from the smooth muscle cells into the extracellular fluid. The Ca2+ efflux from rabbit colon into a Ca2+-free Krebs-Ringer bicarbonate buffer was measured by using a Ca2+-selective electrode. Both anoxia and DNP (6.6 × 10-5M) increased the Ca2+ efflux from the smooth muscle cells. The local anaesthetic D-mepivacaine, at a concentration of 1×10 3M, reduced the increase in Ca2+ efflux and simultaneously enhanced the anoxic or DNP-induced rise in phosphorylase a activity. The replacement of external Na+ by choline was found to reduce the basal Ca2+ efflux and to moderately increase the phosphorylase a activity. On addition of DNP to the Na+-free and Ca2+-free buffer there was no significant change in the Ca2+ efflux, but the increase in phosphorylase a activity was greater than in the physiological buffer containing 137 mM Na+. These observations support the suggestion that anoxia and DNP, by releasing Ca2+ from the mitochondria, increase the phosphorylase a activity of smooth muscle." @default.
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- W2155536596 date "2009-03-13" @default.
- W2155536596 modified "2023-09-27" @default.
- W2155536596 title "Influence of Anoxia and Dinitrophenol on Ca2+ Efflux and Phosphorylase a Activity in Rabbit Colon Smooth Muscle" @default.
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- W2155536596 doi "https://doi.org/10.1111/j.1600-0773.1984.tb01890.x" @default.
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