FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155554726> ?p ?o ?g. }

• W2155554726 endingPage "511" @default.
• W2155554726 startingPage "499" @default.
• W2155554726 abstract "Transcriptional repression mechanisms have emerged as one of the crucial processes for the downregulation of E-cadherin expression during development and tumour progression. Recently, several E-cadherin transcriptional repressors have been characterized (Snail, E12/E47, ZEB-1 and SIP-1) and shown to act through an interaction with proximal E-boxes of the E-cadherin promoter. We have analyzed the participation of another member of the Snail family, Slug, and observed that it also behaves as a repressor of E-cadherin expression. Stable expression of Slug in MDCK cells leads to the full repression of E-cadherin at transcriptional level and triggers a complete epithelial to mesenchymal transition. Slug-induced repression of E-cadherin is mediated by its binding to proximal E-boxes, particularly to the E-pal element of the mouse promoter. Detailed analysis of the binding affinity of different repressors to the E-pal element indicates that Slug binds with lower affinity than Snail and E47 proteins. These results, together with the known expression patterns of these factors in embryonic development and carcinoma cell lines, support the idea that the in vivo action of the different factors in E-cadherin repression can be modulated by their relative concentrations as well as by specific cellular or tumour contexts." @default.
• W2155554726 created "2016-06-24" @default.
• W2155554726 creator A5004949644 @default.
• W2155554726 creator A5010137759 @default.
• W2155554726 creator A5032645016 @default.
• W2155554726 creator A5066955100 @default.
• W2155554726 creator A5075698989 @default.
• W2155554726 creator A5078740280 @default.
• W2155554726 date "2003-02-01" @default.
• W2155554726 modified "2023-10-17" @default.
• W2155554726 title "The transcription factor Slug represses <i>E-cadherin</i> expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors" @default.
• W2155554726 cites W1484020898 @default.
• W2155554726 cites W1507509867 @default.
• W2155554726 cites W1567517848 @default.
• W2155554726 cites W1973046279 @default.
• W2155554726 cites W1974643611 @default.
• W2155554726 cites W1977346307 @default.
• W2155554726 cites W1992159038 @default.
• W2155554726 cites W2006417453 @default.
• W2155554726 cites W2010414816 @default.
• W2155554726 cites W2016414500 @default.
• W2155554726 cites W2021863302 @default.
• W2155554726 cites W2028134580 @default.
• W2155554726 cites W2029848748 @default.
• W2155554726 cites W2033509429 @default.
• W2155554726 cites W2043797012 @default.
• W2155554726 cites W2048303068 @default.
• W2155554726 cites W2052626837 @default.
• W2155554726 cites W2055719575 @default.
• W2155554726 cites W2065832539 @default.
• W2155554726 cites W2068877404 @default.
• W2155554726 cites W2070047455 @default.
• W2155554726 cites W2070136352 @default.
• W2155554726 cites W2073543360 @default.
• W2155554726 cites W2075077815 @default.
• W2155554726 cites W2075640370 @default.
• W2155554726 cites W2081199472 @default.
• W2155554726 cites W2084457841 @default.
• W2155554726 cites W2087367170 @default.
• W2155554726 cites W2090194040 @default.
• W2155554726 cites W2094869461 @default.
• W2155554726 cites W2095688980 @default.
• W2155554726 cites W2108186158 @default.
• W2155554726 cites W2137280750 @default.
• W2155554726 cites W2143375633 @default.
• W2155554726 cites W2146445411 @default.
• W2155554726 cites W2165901622 @default.
• W2155554726 cites W2165987163 @default.
• W2155554726 cites W2326889571 @default.
• W2155554726 cites W2006589984 @default.
• W2155554726 doi "https://doi.org/10.1242/jcs.00224" @default.
• W2155554726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12508111" @default.
• W2155554726 hasPublicationYear "2003" @default.
• W2155554726 type Work @default.
• W2155554726 sameAs 2155554726 @default.
• W2155554726 citedByCount "1032" @default.
• W2155554726 countsByYear W21555547262012 @default.
• W2155554726 countsByYear W21555547262013 @default.
• W2155554726 countsByYear W21555547262014 @default.
• W2155554726 countsByYear W21555547262015 @default.
• W2155554726 countsByYear W21555547262016 @default.
• W2155554726 countsByYear W21555547262017 @default.
• W2155554726 countsByYear W21555547262018 @default.
• W2155554726 countsByYear W21555547262019 @default.
• W2155554726 countsByYear W21555547262020 @default.
• W2155554726 countsByYear W21555547262021 @default.
• W2155554726 countsByYear W21555547262022 @default.
• W2155554726 countsByYear W21555547262023 @default.
• W2155554726 crossrefType "journal-article" @default.
• W2155554726 hasAuthorship W2155554726A5004949644 @default.
• W2155554726 hasAuthorship W2155554726A5010137759 @default.
• W2155554726 hasAuthorship W2155554726A5032645016 @default.
• W2155554726 hasAuthorship W2155554726A5066955100 @default.
• W2155554726 hasAuthorship W2155554726A5075698989 @default.
• W2155554726 hasAuthorship W2155554726A5078740280 @default.
• W2155554726 hasBestOaLocation W21555547262 @default.
• W2155554726 hasConcept C104317684 @default.
• W2155554726 hasConcept C127561419 @default.
• W2155554726 hasConcept C1491633281 @default.
• W2155554726 hasConcept C149402561 @default.
• W2155554726 hasConcept C150194340 @default.
• W2155554726 hasConcept C153911025 @default.
• W2155554726 hasConcept C158448853 @default.
• W2155554726 hasConcept C186310378 @default.
• W2155554726 hasConcept C18903297 @default.
• W2155554726 hasConcept C2779965526 @default.
• W2155554726 hasConcept C2781381752 @default.
• W2155554726 hasConcept C502942594 @default.
• W2155554726 hasConcept C54355233 @default.
• W2155554726 hasConcept C76419328 @default.
• W2155554726 hasConcept C86339819 @default.
• W2155554726 hasConcept C86803240 @default.
• W2155554726 hasConcept C95444343 @default.
• W2155554726 hasConceptScore W2155554726C104317684 @default.
• W2155554726 hasConceptScore W2155554726C127561419 @default.
• W2155554726 hasConceptScore W2155554726C1491633281 @default.
• W2155554726 hasConceptScore W2155554726C149402561 @default.
• W2155554726 hasConceptScore W2155554726C150194340 @default.

• next