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• W2155574242 abstract "FAM176A (family with sequence similarity 176 member A) is a novel molecule related to programmed cell death. A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers. In the present study, we investigated the biological activities of FAM176A on the human non-small cell lung cancer cell line H1299 cells. We constructed a recombinant adenovirus 5-FAM176A vector (Ad5-FAM176A) and evaluated the expression and anti-tumor activities in vitro. Cell viability analysis revealed that the adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy and apoptosis that involved caspase activation. In addition, cell cycle analysis suggested that Ad5-FAM176A could induce cell cycle arrest at the G2/M phase, all of which suggested that adenovirus-mediated FAM176A gene transfer might present a new therapeutic approach for lung cancer treatment." @default.
• W2155574242 created "2016-06-24" @default.
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• W2155574242 date "2014-02-28" @default.
• W2155574242 modified "2023-10-11" @default.
• W2155574242 title "Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells" @default.
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• W2155574242 doi "https://doi.org/10.5483/bmbrep.2014.47.2.090" @default.
• W2155574242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4163899" @default.
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