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• W2155582854 abstract "Whole-cell patch-clamp recordings were performed on acute brain slices of male rats to investigate the ability of the neurons of the median preoptic nucleus (MnPO) to detect fluctuation in extracellular osmolarity and sodium concentration ([Na+]out). Local application of hypotonic and hypertonic artificial CSF hyperpolarized and depolarized the neurons, respectively. Similar responses obtained under synaptic isolation (0.5 microM TTX) highlighted the intrinsic ability of the MnPO neurons to detect changes in extracellular osmolarity and [Na+]out. Manipulating extracellular osmolarity, [Na+]out, and [Cl-]out showed in an independent manner that the MnPO neurons responded to a change in [Na+]out exclusively. The specific Na+ response was voltage insensitive and depended on the driving force for Na+ ions, indicating that a sustained background Na+ permeability controlled the membrane potential of the MnPO neurons. This specific response was not reduced by Gd3+, amiloride, or benzamil, ruling out the participation of mechanosensitive cationic channels, specific epithelial Na+ channels, and Phe-Met-Arg-Phe-gated Na+ channels, respectively. Combination of in situ hybridization, using a riboprobe directed against the atypical Na+ channel (Na(X)), and immunohistochemistry, using an antibody against neuron-specific nuclei protein, revealed that a substantial population of MnPO neurons expressed the Na(X) channel, which was characterized recently as a concentration-sensitive Na+ channel. This study shows that a neuronal population of the MnPO acts as functional Na+ sensors and that the Na(X) channel might represent the molecular basis for the extracellular sodium level sensing in these neurons." @default.
• W2155582854 created "2016-06-24" @default.
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• W2155582854 creator A5041084518 @default.
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• W2155582854 date "2004-04-21" @default.
• W2155582854 modified "2023-09-26" @default.
• W2155582854 title "Specific Na⁺Sensors Are Functionally Expressed in a Neuronal Population of the Median Preoptic Nucleus of the Rat" @default.
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• W2155582854 doi "https://doi.org/10.1523/jneurosci.3720-03.2004" @default.
• W2155582854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729411" @default.
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• W2155582854 hasPublicationYear "2004" @default.
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