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- W2155589321 endingPage "400" @default.
- W2155589321 startingPage "393" @default.
- W2155589321 abstract "The emergence and convergence of cancer genomics, targeted therapies, and network oncology have significantly expanded the landscape of protein-protein interaction (PPI) networks in cancer for therapeutic discovery. Extensive biological and clinical investigations have led to the identification of protein interaction hubs and nodes that are critical for the acquisition and maintenance of characteristics of cancer essential for cell transformation. Such cancer-enabling PPIs have become promising therapeutic targets. With technological advances in PPI modulator discovery and validation of PPI-targeting agents in clinical settings, targeting of PPI interfaces as an anticancer strategy has become a reality. Future research directed at genomics-based PPI target discovery, PPI interface characterization, PPI-focused chemical library design, and patient-genomic subpopulation-driven clinical studies is expected to accelerate the development of the next generation of PPI-based anticancer agents for personalized precision medicine. Here we briefly review prominent PPIs that mediate cancer-acquired properties, highlight recognized challenges and promising clinical results in targeting PPIs, and outline emerging opportunities." @default.
- W2155589321 created "2016-06-24" @default.
- W2155589321 creator A5055201065 @default.
- W2155589321 creator A5059710197 @default.
- W2155589321 creator A5072454821 @default.
- W2155589321 date "2013-07-01" @default.
- W2155589321 modified "2023-10-06" @default.
- W2155589321 title "Targeting protein–protein interactions as an anticancer strategy" @default.
- W2155589321 cites W1203651314 @default.
- W2155589321 cites W1506948354 @default.
- W2155589321 cites W1596376363 @default.
- W2155589321 cites W1618299283 @default.
- W2155589321 cites W1964098656 @default.
- W2155589321 cites W1964333742 @default.
- W2155589321 cites W1970778547 @default.
- W2155589321 cites W1971102429 @default.
- W2155589321 cites W1972765844 @default.
- W2155589321 cites W1974715712 @default.
- W2155589321 cites W1976033223 @default.
- W2155589321 cites W1976261939 @default.
- W2155589321 cites W1978786071 @default.
- W2155589321 cites W1979414133 @default.
- W2155589321 cites W1980621088 @default.
- W2155589321 cites W1986688227 @default.
- W2155589321 cites W1987292778 @default.
- W2155589321 cites W1992041755 @default.
- W2155589321 cites W1992114507 @default.
- W2155589321 cites W1998918148 @default.
- W2155589321 cites W2004038234 @default.
- W2155589321 cites W2005833897 @default.
- W2155589321 cites W2017570679 @default.
- W2155589321 cites W2021493844 @default.
- W2155589321 cites W2023697479 @default.
- W2155589321 cites W2025183726 @default.
- W2155589321 cites W2026254108 @default.
- W2155589321 cites W2030476352 @default.
- W2155589321 cites W2033373463 @default.
- W2155589321 cites W2034619626 @default.
- W2155589321 cites W2036023206 @default.
- W2155589321 cites W2039473152 @default.
- W2155589321 cites W2041535798 @default.
- W2155589321 cites W2042386784 @default.
- W2155589321 cites W2044433401 @default.
- W2155589321 cites W2049172807 @default.
- W2155589321 cites W2053503219 @default.
- W2155589321 cites W2054166362 @default.
- W2155589321 cites W2056169996 @default.
- W2155589321 cites W2059388258 @default.
- W2155589321 cites W2059942519 @default.
- W2155589321 cites W2061016312 @default.
- W2155589321 cites W2066303715 @default.
- W2155589321 cites W2067323612 @default.
- W2155589321 cites W2073356108 @default.
- W2155589321 cites W2077244922 @default.
- W2155589321 cites W2080975591 @default.
- W2155589321 cites W2082047157 @default.
- W2155589321 cites W2083278814 @default.
- W2155589321 cites W2084156403 @default.
- W2155589321 cites W2085419794 @default.
- W2155589321 cites W2085948054 @default.
- W2155589321 cites W2087861588 @default.
- W2155589321 cites W2089626640 @default.
- W2155589321 cites W2090041442 @default.
- W2155589321 cites W2091070883 @default.
- W2155589321 cites W2091208410 @default.
- W2155589321 cites W2094130001 @default.
- W2155589321 cites W2096495293 @default.
- W2155589321 cites W2096797981 @default.
- W2155589321 cites W2097933346 @default.
- W2155589321 cites W2099293745 @default.
- W2155589321 cites W2100323510 @default.
- W2155589321 cites W2102148658 @default.
- W2155589321 cites W2106799894 @default.
- W2155589321 cites W2107319896 @default.
- W2155589321 cites W2110845358 @default.
- W2155589321 cites W2111187586 @default.
- W2155589321 cites W2113438615 @default.
- W2155589321 cites W2117692326 @default.
- W2155589321 cites W2120572492 @default.
- W2155589321 cites W2122772601 @default.
- W2155589321 cites W2123196322 @default.
- W2155589321 cites W2127506367 @default.
- W2155589321 cites W2130891925 @default.
- W2155589321 cites W2136206140 @default.
- W2155589321 cites W2138958920 @default.
- W2155589321 cites W2141715793 @default.
- W2155589321 cites W2153594105 @default.
- W2155589321 cites W2168303063 @default.
- W2155589321 cites W2172242534 @default.
- W2155589321 cites W2314041260 @default.
- W2155589321 cites W2316080015 @default.
- W2155589321 cites W2327156920 @default.
- W2155589321 cites W2570629397 @default.
- W2155589321 cites W26133156 @default.
- W2155589321 cites W40735305 @default.
- W2155589321 cites W4210407906 @default.
- W2155589321 doi "https://doi.org/10.1016/j.tips.2013.04.007" @default.
- W2155589321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3773978" @default.