FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155606031> ?p ?o ?g. }

• W2155606031 endingPage "662" @default.
• W2155606031 startingPage "655" @default.
• W2155606031 abstract "The aim of this study was to identify changes in the gene expression profile of Candida albicans upon exposure to the hydroxypyridone anti-infective agent ciclopirox olamine in an effort to better understand its mechanism of action.C. albicans SC5314 was exposed to either medium alone or ciclopirox olamine at a concentration equivalent to the IC50 (0.24 mg/L) for 3 h. RNA was isolated and gene expression profiles were compared using DNA microarrays. Differential expression of select genes was confirmed by real-time reverse transcription (RT)-PCR. Mutants disrupted for CDR2 and both CDR1 and CDR2, as well as a clinical isolate overexpressing CDR1 and CDR2, were examined for changes in susceptibility to ciclopirox olamine.A total of 49 genes were found to be responsive to ciclopirox olamine, including 36 up-regulated genes and 13 down-regulated genes. These included genes involved in small molecule transport (HGT11, HXT5, ENA22, PHO84, CDR4), iron uptake (FRE30, FET34, FTR1, FTR2, SIT1) and cell stress (SOD1, SOD22, CDR1, DDR48). Mutants disrupted for CDR2 and both CDR1 and CDR2, as well as a clinical isolate overexpressing CDR1 and CDR2, showed no change in susceptibility to ciclopirox olamine compared with the respective parent.Consistent with the hypothesis that ciclopirox olamine acts as an iron chelator, it induced changes in expression of many genes involved in iron uptake. Despite induction of the multidrug efflux pump genes CDR1 and, to a lesser extent, CDR2 by ciclopirox olamine, these genes do not affect susceptibility to this agent." @default.
• W2155606031 created "2016-06-24" @default.
• W2155606031 creator A5008410969 @default.
• W2155606031 creator A5030832172 @default.
• W2155606031 creator A5059280370 @default.
• W2155606031 creator A5081092300 @default.
• W2155606031 creator A5082260796 @default.
• W2155606031 date "2005-05-01" @default.
• W2155606031 modified "2023-09-23" @default.
• W2155606031 title "Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans" @default.
• W2155606031 cites W1972339161 @default.
• W2155606031 cites W1987415607 @default.
• W2155606031 cites W1989849863 @default.
• W2155606031 cites W1998840608 @default.
• W2155606031 cites W2001239365 @default.
• W2155606031 cites W2026517372 @default.
• W2155606031 cites W2038625884 @default.
• W2155606031 cites W2039124161 @default.
• W2155606031 cites W2049505636 @default.
• W2155606031 cites W2053731121 @default.
• W2155606031 cites W2062634906 @default.
• W2155606031 cites W2074775779 @default.
• W2155606031 cites W2075208991 @default.
• W2155606031 cites W2075606510 @default.
• W2155606031 cites W2078454854 @default.
• W2155606031 cites W2090201814 @default.
• W2155606031 cites W2091136135 @default.
• W2155606031 cites W2095902301 @default.
• W2155606031 cites W2102993886 @default.
• W2155606031 cites W2104107099 @default.
• W2155606031 cites W2106248803 @default.
• W2155606031 cites W2107228478 @default.
• W2155606031 cites W2109614049 @default.
• W2155606031 cites W2111022398 @default.
• W2155606031 cites W2114605201 @default.
• W2155606031 cites W2116145373 @default.
• W2155606031 cites W2135989597 @default.
• W2155606031 cites W2144149632 @default.
• W2155606031 cites W2145646735 @default.
• W2155606031 cites W2157766752 @default.
• W2155606031 cites W2378498863 @default.
• W2155606031 cites W318278602 @default.
• W2155606031 cites W84273483 @default.
• W2155606031 doi "https://doi.org/10.1093/jac/dki105" @default.
• W2155606031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15814599" @default.
• W2155606031 hasPublicationYear "2005" @default.
• W2155606031 type Work @default.
• W2155606031 sameAs 2155606031 @default.
• W2155606031 citedByCount "52" @default.
• W2155606031 countsByYear W21556060312012 @default.
• W2155606031 countsByYear W21556060312013 @default.
• W2155606031 countsByYear W21556060312014 @default.
• W2155606031 countsByYear W21556060312015 @default.
• W2155606031 countsByYear W21556060312016 @default.
• W2155606031 countsByYear W21556060312017 @default.
• W2155606031 countsByYear W21556060312018 @default.
• W2155606031 countsByYear W21556060312019 @default.
• W2155606031 countsByYear W21556060312020 @default.
• W2155606031 countsByYear W21556060312021 @default.
• W2155606031 countsByYear W21556060312022 @default.
• W2155606031 countsByYear W21556060312023 @default.
• W2155606031 crossrefType "journal-article" @default.
• W2155606031 hasAuthorship W2155606031A5008410969 @default.
• W2155606031 hasAuthorship W2155606031A5030832172 @default.
• W2155606031 hasAuthorship W2155606031A5059280370 @default.
• W2155606031 hasAuthorship W2155606031A5081092300 @default.
• W2155606031 hasAuthorship W2155606031A5082260796 @default.
• W2155606031 hasBestOaLocation W21556060311 @default.
• W2155606031 hasConcept C104317684 @default.
• W2155606031 hasConcept C143065580 @default.
• W2155606031 hasConcept C150194340 @default.
• W2155606031 hasConcept C200082930 @default.
• W2155606031 hasConcept C2780917455 @default.
• W2155606031 hasConcept C54355233 @default.
• W2155606031 hasConcept C70721500 @default.
• W2155606031 hasConcept C86803240 @default.
• W2155606031 hasConceptScore W2155606031C104317684 @default.
• W2155606031 hasConceptScore W2155606031C143065580 @default.
• W2155606031 hasConceptScore W2155606031C150194340 @default.
• W2155606031 hasConceptScore W2155606031C200082930 @default.
• W2155606031 hasConceptScore W2155606031C2780917455 @default.
• W2155606031 hasConceptScore W2155606031C54355233 @default.
• W2155606031 hasConceptScore W2155606031C70721500 @default.
• W2155606031 hasConceptScore W2155606031C86803240 @default.
• W2155606031 hasIssue "5" @default.
• W2155606031 hasLocation W21556060311 @default.
• W2155606031 hasLocation W21556060312 @default.
• W2155606031 hasOpenAccess W2155606031 @default.
• W2155606031 hasPrimaryLocation W21556060311 @default.
• W2155606031 hasRelatedWork W1974522561 @default.
• W2155606031 hasRelatedWork W2002128513 @default.
• W2155606031 hasRelatedWork W2009966535 @default.
• W2155606031 hasRelatedWork W2064207257 @default.
• W2155606031 hasRelatedWork W2085731811 @default.
• W2155606031 hasRelatedWork W2117110650 @default.
• W2155606031 hasRelatedWork W2153057813 @default.
• W2155606031 hasRelatedWork W2156674132 @default.
• W2155606031 hasRelatedWork W2168243304 @default.

• next