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• W2155607839 abstract "In order to find a way to develop a new treatment for inner ear disorders, the effects of a nitric oxide synthase (NOS) inhibitor [N-nitro-L-arginine methylester (L-NAME)] and a neurotrophin [brain-derived neurotrophic factor (BDNF)] were investigated. The effect of L-NAME and BDNF on gentamicin-induced vestibular hair cell damage was investigated by using the in vitro LIVE/DEAD system. Both L-NAME and BDNF individually reduced the vestibular hair cell damage caused by gentamicin but the combination of L-NAME and BDNF was more successful in preventing damage. It is therefore suggested that treatment with a combination of an NOS inhibitor and a neurotrophin will help us to treat inner ear disorders." @default.
• W2155607839 created "2016-06-24" @default.
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• W2155607839 date "2002-01-01" @default.
• W2155607839 modified "2023-09-26" @default.
• W2155607839 title "Brain-derived Neurotrophic Factor and Nitric Oxide Synthase Inhibitor Protect the Vestibular Organ Against Gentamicin Ototoxicity" @default.
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• W2155607839 doi "https://doi.org/10.1080/00016480252775661" @default.
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