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- W2155619163 abstract "To identify respiratory viruses in infants experiencing their first episode of wheeze hospitalized for lower respiratory illness. We enrolled 70 infants (7.6 ± 6.8 months) hospitalized between August 2009 and June 2012 for acute respiratory symptoms with their first episode of wheeze. Nasopharyngeal swabs were collected after written informed consent was obtained from the patients’ parents, and collected clinical data. The identification of viral genomes, including respiratory syncytial virus (RSV), human rhinovirus (HRV), humanenterovirus, human metapneumovirus, human parainfluenzavirus, influenza virus, adenovirus, and human bocavirus in the sputum/nasal discharge was performed using RT-PCR technique. Slides of sputum were prepared with a cytospin and stained with hematoxylin-eosin for differential cell counts. The patients were followed up for at least 2 years from the first wheeze episodes by clinical examination or phone interview to patients’ mother whether they experienced recurrent wheezing episodes. Eighty six % of infants experiencing their first episode of wheeze were infected with RSV, HRV or their co-infection. Peripheral eosinophil count was 1.8 ± 2.6%, and sputum eosinophil count was 47.6 ± 24.6%. Fifty seven % of infants had experienced recurrent wheezing episodes. Family history of asthma, virus types, and counts of sputum eosinophils were not associated with their recurrent wheezing episodes. Infants with food allergy were significantly associated with the recurrent wheezing episodes (P< 0.05). RSV and HRV are major triggers of first wheeze in infants. Respiratory viruses induce eosinophilic inflammation in their airways. Food allergy is the risk factor of recurrent wheezing episodes." @default.
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- W2155619163 date "2015-02-01" @default.
- W2155619163 modified "2023-09-25" @default.
- W2155619163 title "Respiratory Syncytial Virus and Rhinovirus Contribute to the First Wheeze Episodes in Japanese Infants" @default.
- W2155619163 doi "https://doi.org/10.1016/j.jaci.2014.12.1294" @default.
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