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- W2155621515 endingPage "520" @default.
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- W2155621515 abstract "The objective of this review is to describe the current status of several intravaginal anti-HIV microbicidal delivery systems these delivery systems and microbicidal compounds in the context of their stage within clinical trials and their potential cervicovaginal defence successes. The global Human Immuno-Deficiency Virus (HIV) pandemic continues to spread at a rate of more than 15,000 new infections daily and sexually transmitted infections (STIs) can predispose people to acquiring HIV infection. Male-to-female transmission is eight times more likely to occur than female-to-male transmission due to the anatomical structure of the vagina as well as socio-economic factors and the disempowerment of women that renders them unable to refuse unsafe sexual practices in some communities. The increased incidence of HIV in women has identified the urgent need for efficacious and safe intravaginal delivery of anti-HIV agents that can be used and controlled by women. To meet this challenge, several intravaginal anti-HIV microbicidal delivery systems are in the process of been developed. The outcomes of three main categories are discussed in this review: namely, dual-function polymeric systems, non-polymeric systems and nanotechnology-based systems. These delivery systems include formulations that modify the genital environment (e.g. polyacrylic acid gels and lactobacillus gels), surfactants (e.g. sodium lauryl sulfate), polyanionic therapeutic polymers (e.g. carageenan and carbomer/lactic acid gels), proteins (e.g. cyanovirin-N, monoclonal antibodies and thromspondin-1 peptides), protease inhibitors and other molecules (e.g. dendrimer based-gels and the molecular condom). Intravaginal microbicide delivery systems are providing a new option for preventing the transmission of STIs and HIV." @default.
- W2155621515 created "2016-06-24" @default.
- W2155621515 creator A5003185613 @default.
- W2155621515 creator A5008277699 @default.
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- W2155621515 creator A5046665675 @default.
- W2155621515 creator A5047605857 @default.
- W2155621515 creator A5063886313 @default.
- W2155621515 date "2008-04-02" @default.
- W2155621515 modified "2023-10-05" @default.
- W2155621515 title "A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections" @default.
- W2155621515 cites W148438939 @default.
- W2155621515 cites W1509132217 @default.
- W2155621515 cites W1520349470 @default.
- W2155621515 cites W1586658778 @default.
- W2155621515 cites W1592732258 @default.
- W2155621515 cites W1680765385 @default.
- W2155621515 cites W1819512363 @default.
- W2155621515 cites W1882058356 @default.
- W2155621515 cites W1923759146 @default.
- W2155621515 cites W1926538208 @default.
- W2155621515 cites W1964314503 @default.
- W2155621515 cites W1965331248 @default.
- W2155621515 cites W1965465448 @default.
- W2155621515 cites W1970345858 @default.
- W2155621515 cites W1976234676 @default.
- W2155621515 cites W1979148488 @default.
- W2155621515 cites W1981474525 @default.
- W2155621515 cites W1981520569 @default.
- W2155621515 cites W1985334490 @default.
- W2155621515 cites W1986420453 @default.
- W2155621515 cites W1986918611 @default.
- W2155621515 cites W1988784338 @default.
- W2155621515 cites W1988934233 @default.
- W2155621515 cites W1994304697 @default.
- W2155621515 cites W1994393240 @default.
- W2155621515 cites W1999677970 @default.
- W2155621515 cites W2002586372 @default.
- W2155621515 cites W2009657389 @default.
- W2155621515 cites W2011070615 @default.
- W2155621515 cites W2011308189 @default.
- W2155621515 cites W2014605450 @default.
- W2155621515 cites W2016150512 @default.
- W2155621515 cites W2017991082 @default.
- W2155621515 cites W2018054094 @default.
- W2155621515 cites W2020358670 @default.
- W2155621515 cites W2020394552 @default.
- W2155621515 cites W2020465880 @default.
- W2155621515 cites W2020885659 @default.
- W2155621515 cites W2021244409 @default.
- W2155621515 cites W2021978496 @default.
- W2155621515 cites W2029561253 @default.
- W2155621515 cites W2029939399 @default.
- W2155621515 cites W2032367420 @default.
- W2155621515 cites W2033078166 @default.
- W2155621515 cites W2037111207 @default.
- W2155621515 cites W2038265772 @default.
- W2155621515 cites W2039496381 @default.
- W2155621515 cites W2043559097 @default.
- W2155621515 cites W2044227889 @default.
- W2155621515 cites W2046162941 @default.
- W2155621515 cites W2046938785 @default.
- W2155621515 cites W2048979330 @default.
- W2155621515 cites W2049762776 @default.
- W2155621515 cites W2056478350 @default.
- W2155621515 cites W2057176060 @default.
- W2155621515 cites W2057285090 @default.
- W2155621515 cites W2057847483 @default.
- W2155621515 cites W2068132832 @default.
- W2155621515 cites W2068776200 @default.
- W2155621515 cites W2069080281 @default.
- W2155621515 cites W2074031126 @default.
- W2155621515 cites W2075848378 @default.
- W2155621515 cites W2078206584 @default.
- W2155621515 cites W2079675650 @default.
- W2155621515 cites W2079695706 @default.
- W2155621515 cites W2086701475 @default.
- W2155621515 cites W2087241994 @default.
- W2155621515 cites W2090431672 @default.
- W2155621515 cites W2092016012 @default.
- W2155621515 cites W2094068371 @default.
- W2155621515 cites W2095830444 @default.
- W2155621515 cites W2097305591 @default.
- W2155621515 cites W2098407949 @default.
- W2155621515 cites W2100576440 @default.
- W2155621515 cites W2101650166 @default.
- W2155621515 cites W2101653169 @default.
- W2155621515 cites W2102255881 @default.
- W2155621515 cites W2104815595 @default.
- W2155621515 cites W2104939725 @default.
- W2155621515 cites W2107497511 @default.
- W2155621515 cites W2107800256 @default.
- W2155621515 cites W2108168271 @default.
- W2155621515 cites W2110830680 @default.
- W2155621515 cites W2111773881 @default.
- W2155621515 cites W2119035332 @default.
- W2155621515 cites W2120078856 @default.
- W2155621515 cites W2123680139 @default.