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• W2155631155 abstract "ABSTRACT PerR is a ferric uptake repressor (Fur) homolog that functions as the central regulator of the inducible peroxide stress response in Bacillus subtilis . PerR has been previously demonstrated to regulate the mrgA , katA , ahpCF , hemAXCDBL , and zosA genes. We now demonstrate that PerR also mediates both the repression of its own gene and that of fur . Whereas PerR-mediated repression of most target genes can be elicited by either manganese or iron, repression of perR and fur is selective for manganese. Genetic studies indicate that repression of PerR regulon genes by either manganese or iron requires PerR and is generally independent of Fur. Indeed, in a fur mutant, iron-mediated repression is enhanced. Unexpectedly, repression of the fur gene by manganese appears to require both PerR and Fur, but only PerR binds to the fur regulatory region in vitro. The fur mutation appears to act indirectly by affecting cellular metal ion pools and thereby affecting PerR-mediated repression. While many components of the perR regulon are strongly induced by hydrogen peroxide, little, if any, induction of fur and perR could be demonstrated. Thus, not all components of the PerR regulon are components of the peroxide stimulon. We suggest that PerR exists in distinct metallated forms that differ in DNA target selectivity and in sensitivity to oxidation. This model is supported by the observation that the metal ion composition of the growth medium can greatly influence the transcriptional response of the various PerR regulon genes to hydrogen peroxide." @default.
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• W2155631155 date "2002-06-15" @default.
• W2155631155 modified "2023-10-11" @default.
• W2155631155 title "Regulation of the <i>Bacillus subtilis fur</i> and <i>perR</i> Genes by PerR: Not All Members of the PerR Regulon Are Peroxide Inducible" @default.
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• W2155631155 doi "https://doi.org/10.1128/jb.184.12.3276-3286.2002" @default.
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