FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155648144> ?p ?o ?g. }

• W2155648144 endingPage "1595" @default.
• W2155648144 startingPage "1590" @default.
• W2155648144 abstract "Growth factors and cytokines are present in small quantities in the oviduct and uterus and some are synthesized by the growing embryo. Granulocytes-macrophage colony-stimulating factor (GM-CSF) is known as an important regulator, which enhances cell proliferation and reduces apoptosis in developing blastocysts, during normal fetal and placental development. The purpose of this study is to investigate whether adding GM-CSF to the culture media affects blastulation or the chromosomal status of mouse embryos.Murine embryos were cultured in vitro from the 2-cell stage until the blastocyst stage in the presence of different concentrations of GM-CSF of 0 ng/ml (control), 1, 2, 5 and 10 ng/ml. The development of each embryo was noted and the embryos were then spread for fluorescence in situ hybridization (FISH) using locus-specific probes (LSI) for chromosomes 2, 11 and 16 in all embryos.No difference in the blastulation potential was noted with the addition of 1 and 2 ng/ml of GM-CSF compared with the controls, but there was a significant decrease (P < 0.001) in the blastulation rate in the 5 and 10 ng/ml concentrations. The rate of mosaicism/aneuploidy noted in all GM-CSF groups (1, 2, 5 and 10 ng/ml) was slightly higher than in the control group (0 ng/ml GM-CSF) but the differences were not significant. In the mosaic embryos from the GM-CSF cultured groups, the percentage of aneuploid cells was statistically higher than in the control group.GM-CSF exerted a negative impact on blastocyst development at higher concentrations. GM-CSF did not affect the rates of mosaicism/aneuploidy, but did increase the percentage of aneuploid cells within the mosaic embryos. Adding GM-CSF to the culture media for clinical use requires further studies either on human or animal models to evaluate its long-term effects." @default.
• W2155648144 created "2016-06-24" @default.
• W2155648144 creator A5029226675 @default.
• W2155648144 creator A5031419774 @default.
• W2155648144 creator A5082949438 @default.
• W2155648144 creator A5084057387 @default.
• W2155648144 date "2012-03-29" @default.
• W2155648144 modified "2023-09-27" @default.
• W2155648144 title "The effect of GM-CSF on development and aneuploidy in murine blastocysts" @default.
• W2155648144 cites W1972817655 @default.
• W2155648144 cites W2000575931 @default.
• W2155648144 cites W2012000294 @default.
• W2155648144 cites W2018401567 @default.
• W2155648144 cites W2020564947 @default.
• W2155648144 cites W2030586934 @default.
• W2155648144 cites W2044461908 @default.
• W2155648144 cites W2047612418 @default.
• W2155648144 cites W2053021474 @default.
• W2155648144 cites W2054964979 @default.
• W2155648144 cites W2063312215 @default.
• W2155648144 cites W2079989158 @default.
• W2155648144 cites W2089416232 @default.
• W2155648144 cites W2091675185 @default.
• W2155648144 cites W2096864283 @default.
• W2155648144 cites W2105329229 @default.
• W2155648144 cites W2109086273 @default.
• W2155648144 cites W2112134219 @default.
• W2155648144 cites W2128283484 @default.
• W2155648144 cites W2136295147 @default.
• W2155648144 cites W2147501302 @default.
• W2155648144 cites W2159467731 @default.
• W2155648144 cites W2165910808 @default.
• W2155648144 cites W2167775184 @default.
• W2155648144 cites W4236899648 @default.
• W2155648144 doi "https://doi.org/10.1093/humrep/des108" @default.
• W2155648144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22461004" @default.
• W2155648144 hasPublicationYear "2012" @default.
• W2155648144 type Work @default.
• W2155648144 sameAs 2155648144 @default.
• W2155648144 citedByCount "26" @default.
• W2155648144 countsByYear W21556481442013 @default.
• W2155648144 countsByYear W21556481442014 @default.
• W2155648144 countsByYear W21556481442015 @default.
• W2155648144 countsByYear W21556481442016 @default.
• W2155648144 countsByYear W21556481442018 @default.
• W2155648144 countsByYear W21556481442020 @default.
• W2155648144 countsByYear W21556481442022 @default.
• W2155648144 countsByYear W21556481442023 @default.
• W2155648144 crossrefType "journal-article" @default.
• W2155648144 hasAuthorship W2155648144A5029226675 @default.
• W2155648144 hasAuthorship W2155648144A5031419774 @default.
• W2155648144 hasAuthorship W2155648144A5082949438 @default.
• W2155648144 hasAuthorship W2155648144A5084057387 @default.
• W2155648144 hasBestOaLocation W21556481441 @default.
• W2155648144 hasConcept C104317684 @default.
• W2155648144 hasConcept C129536746 @default.
• W2155648144 hasConcept C134018914 @default.
• W2155648144 hasConcept C153911025 @default.
• W2155648144 hasConcept C16685009 @default.
• W2155648144 hasConcept C196843134 @default.
• W2155648144 hasConcept C2777129507 @default.
• W2155648144 hasConcept C2778177303 @default.
• W2155648144 hasConcept C2779335785 @default.
• W2155648144 hasConcept C2779672484 @default.
• W2155648144 hasConcept C30481170 @default.
• W2155648144 hasConcept C54355233 @default.
• W2155648144 hasConcept C6047887 @default.
• W2155648144 hasConcept C71924100 @default.
• W2155648144 hasConcept C86803240 @default.
• W2155648144 hasConcept C87073359 @default.
• W2155648144 hasConceptScore W2155648144C104317684 @default.
• W2155648144 hasConceptScore W2155648144C129536746 @default.
• W2155648144 hasConceptScore W2155648144C134018914 @default.
• W2155648144 hasConceptScore W2155648144C153911025 @default.
• W2155648144 hasConceptScore W2155648144C16685009 @default.
• W2155648144 hasConceptScore W2155648144C196843134 @default.
• W2155648144 hasConceptScore W2155648144C2777129507 @default.
• W2155648144 hasConceptScore W2155648144C2778177303 @default.
• W2155648144 hasConceptScore W2155648144C2779335785 @default.
• W2155648144 hasConceptScore W2155648144C2779672484 @default.
• W2155648144 hasConceptScore W2155648144C30481170 @default.
• W2155648144 hasConceptScore W2155648144C54355233 @default.
• W2155648144 hasConceptScore W2155648144C6047887 @default.
• W2155648144 hasConceptScore W2155648144C71924100 @default.
• W2155648144 hasConceptScore W2155648144C86803240 @default.
• W2155648144 hasConceptScore W2155648144C87073359 @default.
• W2155648144 hasIssue "6" @default.
• W2155648144 hasLocation W21556481441 @default.
• W2155648144 hasLocation W21556481442 @default.
• W2155648144 hasOpenAccess W2155648144 @default.
• W2155648144 hasPrimaryLocation W21556481441 @default.
• W2155648144 hasRelatedWork W1975720604 @default.
• W2155648144 hasRelatedWork W2037571547 @default.
• W2155648144 hasRelatedWork W2058328895 @default.
• W2155648144 hasRelatedWork W2085360111 @default.
• W2155648144 hasRelatedWork W2085807886 @default.
• W2155648144 hasRelatedWork W2153966430 @default.
• W2155648144 hasRelatedWork W2312857793 @default.

• next