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• W2155655160 endingPage "442" @default.
• W2155655160 startingPage "430" @default.
• W2155655160 abstract "Transient outward channels have a different impact on action potential configuration in small mammals compared to large mammals. Small mammals depend primarily on Ito1 for repolarization, while in larger animals Ito1 only indirectly determines action potential duration by setting the level of the plateau. Transient outward channel expression and distribution also differ between animal species. Nevertheless, the primary protein sequence of the underlying Kv1.4, Kv4.2 and Kv4.3 α1-subunits displays remarkably high levels of amino acid identity. Transient outward channels are subject to α- and β-adrenergic regulation, mainly decreasing Ito1. However, adrenergic stimulation is also an important determinant of transient outward channel downregulation in cardiac disease. Adrenergic stimulation of PKA as well as PKC leads to an inhibition of Ito1, which has been correlated with phosphorylation of the Kv1.4, Kv4.2 and Kv4.3 α1-subunits. Calmodulin-dependent kinase II, on the other hand, has been shown to be involved in an increase of Ito1. Comparison of Kv1.4, Kv4.2 and Kv4.3 primary amino acid sequences demonstrates a strong conservation of (potential) phosphorylation sites between different species, despite the fact that Ito1 has a different effect on action potential configuration in mammalian species." @default.
• W2155655160 created "2016-06-24" @default.
• W2155655160 creator A5003406700 @default.
• W2155655160 creator A5009852139 @default.
• W2155655160 creator A5090220768 @default.
• W2155655160 date "2006-08-01" @default.
• W2155655160 modified "2023-10-16" @default.
• W2155655160 title "Molecular aspects of adrenergic modulation of the transient outward current" @default.
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