Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155656601> ?p ?o ?g. }
- W2155656601 endingPage "735" @default.
- W2155656601 startingPage "723" @default.
- W2155656601 abstract "Hyperhomocysteinemia is a recognized risk factor for cognitive decline and incident dementia in older adults. Two recent reports addressed the cumulative epidemiological evidence for this association but expressed conflicting opinions. Here, the evidence is reviewed in relation to Sir Austin Bradford Hill’s criteria for assessing “causality,” and the latest meta-analysis of the effects of homocysteine-lowering on cognitive function is critically examined. The meta-analysis included 11 trials, collectively assessing 22 000 individuals, that examined the effects of B vitamin supplements (folic acid, vitamin B12, vitamin B6) on global or domain-specific cognitive decline. It concluded that homocysteine-lowering with B vitamin supplements has no significant effect on cognitive function. However, careful examination of the trials in the meta-analysis indicates that no conclusion can be made regarding the effects of homocysteine-lowering on cognitive decline, since the trials typically did not include individuals who were experiencing such decline. Further definitive trials in older adults experiencing cognitive decline are still urgently needed." @default.
- W2155656601 created "2016-06-24" @default.
- W2155656601 creator A5040268724 @default.
- W2155656601 creator A5073118766 @default.
- W2155656601 date "2015-08-18" @default.
- W2155656601 modified "2023-09-30" @default.
- W2155656601 title "Assessing the association between homocysteine and cognition: reflections on Bradford Hill, meta-analyses, and causality" @default.
- W2155656601 cites W1532009682 @default.
- W2155656601 cites W1533350566 @default.
- W2155656601 cites W1762583610 @default.
- W2155656601 cites W1837131274 @default.
- W2155656601 cites W1847168837 @default.
- W2155656601 cites W1945057946 @default.
- W2155656601 cites W1962552915 @default.
- W2155656601 cites W1970975032 @default.
- W2155656601 cites W1982070737 @default.
- W2155656601 cites W1982492435 @default.
- W2155656601 cites W1982802870 @default.
- W2155656601 cites W1996233154 @default.
- W2155656601 cites W2003694812 @default.
- W2155656601 cites W2008645377 @default.
- W2155656601 cites W2011582832 @default.
- W2155656601 cites W2011649457 @default.
- W2155656601 cites W2013204019 @default.
- W2155656601 cites W2032613394 @default.
- W2155656601 cites W2032713105 @default.
- W2155656601 cites W2043522411 @default.
- W2155656601 cites W2049087791 @default.
- W2155656601 cites W2050067614 @default.
- W2155656601 cites W2050266389 @default.
- W2155656601 cites W2052588755 @default.
- W2155656601 cites W2052792956 @default.
- W2155656601 cites W2053364518 @default.
- W2155656601 cites W2063618925 @default.
- W2155656601 cites W2064210726 @default.
- W2155656601 cites W2069767789 @default.
- W2155656601 cites W2073946093 @default.
- W2155656601 cites W2084783700 @default.
- W2155656601 cites W2099614709 @default.
- W2155656601 cites W2108484297 @default.
- W2155656601 cites W2109544293 @default.
- W2155656601 cites W2110118235 @default.
- W2155656601 cites W2113198638 @default.
- W2155656601 cites W2117673398 @default.
- W2155656601 cites W2121060920 @default.
- W2155656601 cites W2125896627 @default.
- W2155656601 cites W2126230337 @default.
- W2155656601 cites W2129542545 @default.
- W2155656601 cites W2131639327 @default.
- W2155656601 cites W2136057401 @default.
- W2155656601 cites W2138622161 @default.
- W2155656601 cites W2148027524 @default.
- W2155656601 cites W2148917936 @default.
- W2155656601 cites W2150229065 @default.
- W2155656601 cites W2153415741 @default.
- W2155656601 cites W2156635660 @default.
- W2155656601 cites W2156997639 @default.
- W2155656601 cites W2159172867 @default.
- W2155656601 cites W2165136235 @default.
- W2155656601 cites W2188754018 @default.
- W2155656601 cites W2335709753 @default.
- W2155656601 cites W2605006141 @default.
- W2155656601 cites W273711101 @default.
- W2155656601 cites W27754594 @default.
- W2155656601 cites W4236548161 @default.
- W2155656601 cites W4247938048 @default.
- W2155656601 cites W4248412990 @default.
- W2155656601 cites W4249034646 @default.
- W2155656601 doi "https://doi.org/10.1093/nutrit/nuv022" @default.
- W2155656601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26293664" @default.
- W2155656601 hasPublicationYear "2015" @default.
- W2155656601 type Work @default.
- W2155656601 sameAs 2155656601 @default.
- W2155656601 citedByCount "53" @default.
- W2155656601 countsByYear W21556566012015 @default.
- W2155656601 countsByYear W21556566012016 @default.
- W2155656601 countsByYear W21556566012017 @default.
- W2155656601 countsByYear W21556566012018 @default.
- W2155656601 countsByYear W21556566012019 @default.
- W2155656601 countsByYear W21556566012020 @default.
- W2155656601 countsByYear W21556566012021 @default.
- W2155656601 countsByYear W21556566012022 @default.
- W2155656601 countsByYear W21556566012023 @default.
- W2155656601 crossrefType "journal-article" @default.
- W2155656601 hasAuthorship W2155656601A5040268724 @default.
- W2155656601 hasAuthorship W2155656601A5073118766 @default.
- W2155656601 hasConcept C118552586 @default.
- W2155656601 hasConcept C121332964 @default.
- W2155656601 hasConcept C126322002 @default.
- W2155656601 hasConcept C15744967 @default.
- W2155656601 hasConcept C169900460 @default.
- W2155656601 hasConcept C2776523773 @default.
- W2155656601 hasConcept C2777090595 @default.
- W2155656601 hasConcept C2779134260 @default.
- W2155656601 hasConcept C2779483572 @default.
- W2155656601 hasConcept C2984863031 @default.
- W2155656601 hasConcept C3020471959 @default.
- W2155656601 hasConcept C62520636 @default.