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- W2155667050 abstract "Fever, an important component of the host's defense response to immune challenge, is absent or attenuated in rats near the term of pregnancy. The present experiments were carried out to determine the role of endogenous glucocorticoids in mediating the altered core temperature (Tc) response to exogenous pyrogen (i.e., Escherichia coli LPS). For the experiments, metyrapone—a glucocorticoid synthesis inhibitor—was administered to near-term pregnant rats prior to an EC 100 dose of E. coli LPS. Administration of LPS following vehicle elicited a significant corticosterone response and resulted in a decrease in Tc (i.e., hypothermia). Prior administration of metyrapone, however, which abolished the corticosterone response and altered the pyrogenic/cryogenic cytokine response to LPS, eliminated hypothermia and restored the febrile response. Our results provide evidence that endogenous glucocorticoids play a role in mediating the altered febrile response to immune stimuli observed in rats near the term of pregnancy." @default.
- W2155667050 created "2016-06-24" @default.
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- W2155667050 date "2011-06-01" @default.
- W2155667050 modified "2023-10-03" @default.
- W2155667050 title "Metyrapone restores the febrile response to Escherichia coli LPS in pregnant rats" @default.
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- W2155667050 doi "https://doi.org/10.1152/ajpregu.00785.2010" @default.
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