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• W2155675049 abstract "The conserved Target of Rapamycin (TOR) kinase forms high molecular mass complexes and is a major regulator of cellular adaptations to environmental cues. The Lethal with Sec Thirteen 8/G protein β subunit-like (LST8/GβL) protein is a member of the TOR complexes, and two putative LST8 genes are present in Arabidopsis thaliana, of which only one (LST8-1) is significantly expressed. The Arabidopsis LST8-1 protein is able to complement yeast lst8 mutations and interacts with the TOR kinase. Mutations in the LST8-1 gene resulted in reduced vegetative growth and apical dominance with abnormal development of flowers. Mutant plants were also highly sensitive to long days and accumulated, like TOR RNA interference lines, higher amounts of starch and amino acids, including proline and glutamine, while showing reduced concentrations of inositol and raffinose. Accordingly, transcriptomic and enzymatic analyses revealed a higher expression of genes involved in nitrate assimilation when lst8-1 mutants were shifted to long days. The transcriptome of lst8-1 mutants in long days was found to share similarities with that of a myo-inositol 1 phosphate synthase mutant that is also sensitive to the extension of the light period. It thus appears that the LST8-1 protein has an important role in regulating amino acid accumulation and the synthesis of myo-inositol and raffinose during plant adaptation to long days." @default.
• W2155675049 created "2016-06-24" @default.
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• W2155675049 date "2012-02-01" @default.
• W2155675049 modified "2023-10-16" @default.
• W2155675049 title "Mutations in the <i>Arabidopsis</i> Homolog of LST8/GβL, a Partner of the Target of Rapamycin Kinase, Impair Plant Growth, Flowering, and Metabolic Adaptation to Long Days" @default.
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• W2155675049 doi "https://doi.org/10.1105/tpc.111.091306" @default.
• W2155675049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315227" @default.
• W2155675049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22307851" @default.
• W2155675049 hasPublicationYear "2012" @default.
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