FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155682285> ?p ?o ?g. }

• W2155682285 endingPage "C171" @default.
• W2155682285 startingPage "C164" @default.
• W2155682285 abstract "Electrophysiological studies of rat islet cells in monolayer culture were undertaken to determine the role of transmembranous ionic fluxes in the inhibitory action of somatostatin on insulin release. In the presence of somatotropin release inhibiting factor (SRIF) (2.5 nM), hyperpolarization occured with or without glucose (16.6 mM) in the medium. SRIF also inhibited the incidence of glucose-induced spike activity. The inhibitory action of SRIF occurred within 5 min and was readily reversible. An increase in extracellular K+ (5-13 mM) or Ca2+ (2.3-4.6 mM) prevented SRIF inhibition of glucose-induced electrical activity. The secretory response of cultured islets to glucose (16.6 mM) was completely inhibited by SRIF (2.5 nM). The presence of high [Ca2+]o or [k+]o enhanced insulin release in the presence of SRIF and glucose. Although phentolamine (5.0 microgram/ml) did not block the inhibition of glucose-induced electrical responses by SRIF, it prevented the inhibitory action of epinephrine (0.2 microgram/ml). It is concluded that the primary action of SRIF is to alter transmembranous cationic fluxes, as manifested by hyperpolarization and a decrease in the incidence of spike activity, which may prevent glucose from eliciting a normal secretory response." @default.
• W2155682285 created "2016-06-24" @default.
• W2155682285 creator A5004112202 @default.
• W2155682285 creator A5017347204 @default.
• W2155682285 creator A5057450804 @default.
• W2155682285 creator A5071194589 @default.
• W2155682285 date "1977-11-01" @default.
• W2155682285 modified "2023-10-15" @default.
• W2155682285 title "Somatostatin inhibition of glucose-induced electrical activity in cultured rat islet cells" @default.
• W2155682285 cites W1819508140 @default.
• W2155682285 cites W1963799051 @default.
• W2155682285 cites W1971242316 @default.
• W2155682285 cites W1975917180 @default.
• W2155682285 cites W1979998538 @default.
• W2155682285 cites W1981904766 @default.
• W2155682285 cites W1989048788 @default.
• W2155682285 cites W1993231398 @default.
• W2155682285 cites W1996876777 @default.
• W2155682285 cites W1996876787 @default.
• W2155682285 cites W1998298455 @default.
• W2155682285 cites W2016519429 @default.
• W2155682285 cites W2035571338 @default.
• W2155682285 cites W2039242258 @default.
• W2155682285 cites W2041471831 @default.
• W2155682285 cites W2041490818 @default.
• W2155682285 cites W2043463618 @default.
• W2155682285 cites W2048105672 @default.
• W2155682285 cites W2056527808 @default.
• W2155682285 cites W2065408322 @default.
• W2155682285 cites W2070403114 @default.
• W2155682285 cites W2071310612 @default.
• W2155682285 cites W2072815941 @default.
• W2155682285 cites W2078502575 @default.
• W2155682285 cites W2082358964 @default.
• W2155682285 cites W2092809791 @default.
• W2155682285 cites W2122269672 @default.
• W2155682285 cites W2122394200 @default.
• W2155682285 cites W2130956345 @default.
• W2155682285 cites W2156854937 @default.
• W2155682285 cites W2157626088 @default.
• W2155682285 cites W2159074670 @default.
• W2155682285 cites W2229716769 @default.
• W2155682285 doi "https://doi.org/10.1152/ajpcell.1977.233.5.c164" @default.
• W2155682285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/335898" @default.
• W2155682285 hasPublicationYear "1977" @default.
• W2155682285 type Work @default.
• W2155682285 sameAs 2155682285 @default.
• W2155682285 citedByCount "22" @default.
• W2155682285 countsByYear W21556822852017 @default.
• W2155682285 countsByYear W21556822852022 @default.
• W2155682285 crossrefType "journal-article" @default.
• W2155682285 hasAuthorship W2155682285A5004112202 @default.
• W2155682285 hasAuthorship W2155682285A5017347204 @default.
• W2155682285 hasAuthorship W2155682285A5057450804 @default.
• W2155682285 hasAuthorship W2155682285A5071194589 @default.
• W2155682285 hasConcept C126322002 @default.
• W2155682285 hasConcept C131453863 @default.
• W2155682285 hasConcept C134018914 @default.
• W2155682285 hasConcept C165220095 @default.
• W2155682285 hasConcept C17077164 @default.
• W2155682285 hasConcept C178790620 @default.
• W2155682285 hasConcept C185592680 @default.
• W2155682285 hasConcept C2776297358 @default.
• W2155682285 hasConcept C2779306644 @default.
• W2155682285 hasConcept C28406088 @default.
• W2155682285 hasConcept C55493867 @default.
• W2155682285 hasConcept C66974803 @default.
• W2155682285 hasConcept C71924100 @default.
• W2155682285 hasConcept C86803240 @default.
• W2155682285 hasConceptScore W2155682285C126322002 @default.
• W2155682285 hasConceptScore W2155682285C131453863 @default.
• W2155682285 hasConceptScore W2155682285C134018914 @default.
• W2155682285 hasConceptScore W2155682285C165220095 @default.
• W2155682285 hasConceptScore W2155682285C17077164 @default.
• W2155682285 hasConceptScore W2155682285C178790620 @default.
• W2155682285 hasConceptScore W2155682285C185592680 @default.
• W2155682285 hasConceptScore W2155682285C2776297358 @default.
• W2155682285 hasConceptScore W2155682285C2779306644 @default.
• W2155682285 hasConceptScore W2155682285C28406088 @default.
• W2155682285 hasConceptScore W2155682285C55493867 @default.
• W2155682285 hasConceptScore W2155682285C66974803 @default.
• W2155682285 hasConceptScore W2155682285C71924100 @default.
• W2155682285 hasConceptScore W2155682285C86803240 @default.
• W2155682285 hasIssue "5" @default.
• W2155682285 hasLocation W21556822851 @default.
• W2155682285 hasLocation W21556822852 @default.
• W2155682285 hasOpenAccess W2155682285 @default.
• W2155682285 hasPrimaryLocation W21556822851 @default.
• W2155682285 hasRelatedWork W168626963 @default.
• W2155682285 hasRelatedWork W1965464649 @default.
• W2155682285 hasRelatedWork W1998060356 @default.
• W2155682285 hasRelatedWork W1998656097 @default.
• W2155682285 hasRelatedWork W2006277196 @default.
• W2155682285 hasRelatedWork W2037108329 @default.
• W2155682285 hasRelatedWork W2044777260 @default.
• W2155682285 hasRelatedWork W2066399525 @default.
• W2155682285 hasRelatedWork W2092893375 @default.
• W2155682285 hasRelatedWork W2415441532 @default.

• next