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• W2155683931 abstract "Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission.Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin.Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p<0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels.Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea.NCT01136850." @default.
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• W2155683931 date "2015-05-26" @default.
• W2155683931 modified "2023-10-15" @default.
• W2155683931 title "Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission" @default.
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• W2155683931 doi "https://doi.org/10.1186/s12936-015-0736-x" @default.
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