FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155687923> ?p ?o ?g. }

• W2155687923 endingPage "20" @default.
• W2155687923 startingPage "20" @default.
• W2155687923 abstract "The study of the potential risks associated with the manufacture, use, and disposal of nanoscale materials, and their mechanisms of toxicity, is important for the continued advancement of nanotechnology. Currently, the most widely accepted paradigms of nanomaterial toxicity are oxidative stress and inflammation, but the underlying mechanisms are poorly defined. This review will highlight the significance of autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Most endocytic routes of nanomaterial cell uptake converge upon the lysosome, making the lysosomal compartment the most common intracellular site of nanoparticle sequestration and degradation. In addition to the endo-lysosomal pathway, recent evidence suggests that some nanomaterials can also induce autophagy. Among the many physiological functions, the lysosome, by way of the autophagy (macroautophagy) pathway, degrades intracellular pathogens, and damaged organelles and proteins. Thus, autophagy induction by nanoparticles may be an attempt to degrade what is perceived by the cell as foreign or aberrant. While the autophagy and endo-lysosomal pathways have the potential to influence the disposition of nanomaterials, there is also a growing body of literature suggesting that biopersistent nanomaterials can, in turn, negatively impact these pathways. Indeed, there is ample evidence that biopersistent nanomaterials can cause autophagy and lysosomal dysfunctions resulting in toxicological consequences." @default.
• W2155687923 created "2016-06-24" @default.
• W2155687923 creator A5031954491 @default.
• W2155687923 creator A5033952203 @default.
• W2155687923 creator A5068625144 @default.
• W2155687923 date "2012-01-01" @default.
• W2155687923 modified "2023-10-16" @default.
• W2155687923 title "Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity" @default.
• W2155687923 cites W10640494 @default.
• W2155687923 cites W1136070835 @default.
• W2155687923 cites W129367412 @default.
• W2155687923 cites W1561835222 @default.
• W2155687923 cites W1562156325 @default.
• W2155687923 cites W1575798288 @default.
• W2155687923 cites W1585705786 @default.
• W2155687923 cites W1760104666 @default.
• W2155687923 cites W1965600613 @default.
• W2155687923 cites W1967111894 @default.
• W2155687923 cites W1969457012 @default.
• W2155687923 cites W1969708446 @default.
• W2155687923 cites W1970029768 @default.
• W2155687923 cites W1971076992 @default.
• W2155687923 cites W1980414709 @default.
• W2155687923 cites W1981904613 @default.
• W2155687923 cites W1982722982 @default.
• W2155687923 cites W1984122112 @default.
• W2155687923 cites W1985455212 @default.
• W2155687923 cites W1986076794 @default.
• W2155687923 cites W1988459632 @default.
• W2155687923 cites W1993467627 @default.
• W2155687923 cites W1996112060 @default.
• W2155687923 cites W2002640507 @default.
• W2155687923 cites W2002936944 @default.
• W2155687923 cites W2003110090 @default.
• W2155687923 cites W2003651291 @default.
• W2155687923 cites W2005997790 @default.
• W2155687923 cites W2007740557 @default.
• W2155687923 cites W2011501261 @default.
• W2155687923 cites W2011645084 @default.
• W2155687923 cites W2012319331 @default.
• W2155687923 cites W2013112981 @default.
• W2155687923 cites W2014790153 @default.
• W2155687923 cites W2017424821 @default.
• W2155687923 cites W2021499254 @default.
• W2155687923 cites W2023413351 @default.
• W2155687923 cites W2024120580 @default.
• W2155687923 cites W2025364264 @default.
• W2155687923 cites W2025996121 @default.
• W2155687923 cites W2027013223 @default.
• W2155687923 cites W2031663496 @default.
• W2155687923 cites W2034657763 @default.
• W2155687923 cites W2035071395 @default.
• W2155687923 cites W2041009706 @default.
• W2155687923 cites W2042767581 @default.
• W2155687923 cites W2045561438 @default.
• W2155687923 cites W2046250764 @default.
• W2155687923 cites W2048711221 @default.
• W2155687923 cites W2049376325 @default.
• W2155687923 cites W2049844684 @default.
• W2155687923 cites W2050960188 @default.
• W2155687923 cites W2051062186 @default.
• W2155687923 cites W2053567796 @default.
• W2155687923 cites W2055793916 @default.
• W2155687923 cites W2057387129 @default.
• W2155687923 cites W2059210685 @default.
• W2155687923 cites W2061347886 @default.
• W2155687923 cites W2062146403 @default.
• W2155687923 cites W2068159429 @default.
• W2155687923 cites W2068756837 @default.
• W2155687923 cites W2071798040 @default.
• W2155687923 cites W2072679909 @default.
• W2155687923 cites W2072755860 @default.
• W2155687923 cites W2073804467 @default.
• W2155687923 cites W2075409966 @default.
• W2155687923 cites W2076107153 @default.
• W2155687923 cites W2077732560 @default.
• W2155687923 cites W2079282879 @default.
• W2155687923 cites W2080241938 @default.
• W2155687923 cites W2080637633 @default.
• W2155687923 cites W2083989124 @default.
• W2155687923 cites W2084329490 @default.
• W2155687923 cites W2084569287 @default.
• W2155687923 cites W2086579338 @default.
• W2155687923 cites W2088002295 @default.
• W2155687923 cites W2093863466 @default.
• W2155687923 cites W2093872487 @default.
• W2155687923 cites W2094399039 @default.
• W2155687923 cites W2096308078 @default.
• W2155687923 cites W2102388619 @default.
• W2155687923 cites W2103972359 @default.
• W2155687923 cites W2105058961 @default.
• W2155687923 cites W2105342909 @default.
• W2155687923 cites W2106195012 @default.
• W2155687923 cites W2106782035 @default.
• W2155687923 cites W2109826292 @default.
• W2155687923 cites W2111031157 @default.
• W2155687923 cites W2113118283 @default.
• W2155687923 cites W2114938079 @default.

• next