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- W2155694815 abstract "Allotyping of the major histocompatibility complex (MHC)-linked complement component C4 has revealed a strong association of the null allele, C4A*Q0, with systemic sclerosis (SSc). Sixty-four percent of patients with SSc carried the C4A*Q0 allele, compared with 17% of the control group. Twenty-five patients and their families were typed for HLA antigens (A, B, Cw, and DR) and the MHC-linked complement components C4 and factor B to identify haplotypes in the MHC linkage group and C4 null alleles. Strong allelic association of HLA-B8 and DR3 with C4A*Q0 probably explains the previously reported association of SSc with the extended haplotype carrying HLA-B8 and DR3. Ninety-two percent of the patients had either C4A*Q0 or DR5; 31% of the controls had either C4A*Q0 or DR5." @default.
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- W2155694815 date "1986-10-01" @default.
- W2155694815 modified "2023-09-27" @default.
- W2155694815 title "A strong association between null alleles at the C4A locus in the major histocompatibility complex and systemic sclerosis" @default.
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- W2155694815 doi "https://doi.org/10.1002/art.1780291014" @default.
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