FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155695972> ?p ?o ?g. }

• W2155695972 endingPage "100" @default.
• W2155695972 startingPage "94" @default.
• W2155695972 abstract "Skeletal muscle myopathy is a hallmark of chronic heart failure (HF). Phenotypic changes involve shift in myosin heavy chain (MHC) fiber type from oxidative, MHC type I, towards more glycolytic MHC IIx fibers, reductions in oxidative enzyme activity, and increase in glycolytic enzyme activity. However, it is unknown if muscle myopathy is reversed following heart transplantation. The purpose of this study was to determine the effect of heart transplantation on skeletal muscle metabolic enzyme reserve and MHC fiber type in end-stage HF patients.Thirteen HF subjects were prospectively studied before and two months after heart transplantation and a subgroup (n = 6) at eight months after transplantation. Skeletal muscle biopsy of the vastus lateralis was performed and relative MHC composition was determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lactate dehydrogenase (LDH), citrate synthase (CS), and 3-hydroxyacyl-CoA-dehydrogenase (HACoA) enzyme activity assays were performed to assess glycolytic, oxidative, and beta-oxidative metabolic enzyme reserves, respectively.Lactate dehydrogenase activity (130.5 +/- 13.3 vs. 106.1 +/- 13.2 micromol/g wet wt/min, p < 0.05), CS activity (14.0 +/- 1.2 vs. 9 +/- 0.9 micromol/g wet wt/min, p < 0.05), and HACoA activity (4.5 +/- 0.48 vs. 3.6 +/- 0.3 micromol/g wet wt/min, p < 0.05) decreased two months after heart transplantation. At eight months, LDH activity was restored (139.0 +/- 11 micromol/g wet wt/min), but not CS or HACoA activity compared with before transplantation. There was no significant change in muscle %MHC type I (28.7 +/- 3.5% vs. 25.3 +/- 3.0%, p = NS), %MHC type IIa (33.2 +/- 2.0% vs. 34.6 +/- 1.9%, p = NS), or %MHC type IIx (38.1 +/- 2.8% vs. 40.1 +/- 3.7%, p = NS) fiber type two months after heart transplantation. However, %MHC type I (19.3 +/- 6.6%) was decreased and %MHC type IIx (51.0 +/- 6.5%) was increased at eight months after (p < 0.05) compared with before transplantation.Skeletal muscle glycolytic, oxidative, and beta-oxidative enzymatic reserves are diminished early after heart transplantation, with reduced oxidative capacity persisting late in the first year. The myopathic MHC phenotype present in end-stage HF persists early in the post-operative state and declines further by eight months." @default.
• W2155695972 created "2016-06-24" @default.
• W2155695972 creator A5002595928 @default.
• W2155695972 creator A5008970152 @default.
• W2155695972 creator A5034221747 @default.
• W2155695972 creator A5065481567 @default.
• W2155695972 creator A5069068136 @default.
• W2155695972 creator A5086186065 @default.
• W2155695972 creator A5090442797 @default.
• W2155695972 date "2007-01-01" @default.
• W2155695972 modified "2023-10-17" @default.
• W2155695972 title "Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients" @default.
• W2155695972 cites W1544944356 @default.
• W2155695972 cites W1965107370 @default.
• W2155695972 cites W1966785364 @default.
• W2155695972 cites W1970677949 @default.
• W2155695972 cites W1983076149 @default.
• W2155695972 cites W1985477620 @default.
• W2155695972 cites W2001920248 @default.
• W2155695972 cites W2002479494 @default.
• W2155695972 cites W2006672778 @default.
• W2155695972 cites W2014399504 @default.
• W2155695972 cites W2014973790 @default.
• W2155695972 cites W2020175156 @default.
• W2155695972 cites W2020721486 @default.
• W2155695972 cites W2025548314 @default.
• W2155695972 cites W2026531291 @default.
• W2155695972 cites W2031180859 @default.
• W2155695972 cites W2042284908 @default.
• W2155695972 cites W2042657552 @default.
• W2155695972 cites W2049504813 @default.
• W2155695972 cites W2057322951 @default.
• W2155695972 cites W2065910271 @default.
• W2155695972 cites W2085403456 @default.
• W2155695972 cites W2086668012 @default.
• W2155695972 cites W2091553398 @default.
• W2155695972 cites W2101175755 @default.
• W2155695972 cites W2141352253 @default.
• W2155695972 cites W2151267784 @default.
• W2155695972 cites W2152008380 @default.
• W2155695972 cites W4293247451 @default.
• W2155695972 doi "https://doi.org/10.1111/j.1399-0012.2006.00589.x" @default.
• W2155695972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17302597" @default.
• W2155695972 hasPublicationYear "2007" @default.
• W2155695972 type Work @default.
• W2155695972 sameAs 2155695972 @default.
• W2155695972 citedByCount "11" @default.
• W2155695972 countsByYear W21556959722013 @default.
• W2155695972 countsByYear W21556959722016 @default.
• W2155695972 countsByYear W21556959722018 @default.
• W2155695972 countsByYear W21556959722020 @default.
• W2155695972 countsByYear W21556959722021 @default.
• W2155695972 crossrefType "journal-article" @default.
• W2155695972 hasAuthorship W2155695972A5002595928 @default.
• W2155695972 hasAuthorship W2155695972A5008970152 @default.
• W2155695972 hasAuthorship W2155695972A5034221747 @default.
• W2155695972 hasAuthorship W2155695972A5065481567 @default.
• W2155695972 hasAuthorship W2155695972A5069068136 @default.
• W2155695972 hasAuthorship W2155695972A5086186065 @default.
• W2155695972 hasAuthorship W2155695972A5090442797 @default.
• W2155695972 hasConcept C111133373 @default.
• W2155695972 hasConcept C126322002 @default.
• W2155695972 hasConcept C134018914 @default.
• W2155695972 hasConcept C181199279 @default.
• W2155695972 hasConcept C20251656 @default.
• W2155695972 hasConcept C2777300911 @default.
• W2155695972 hasConcept C2777318727 @default.
• W2155695972 hasConcept C2778198053 @default.
• W2155695972 hasConcept C2778849806 @default.
• W2155695972 hasConcept C2779959927 @default.
• W2155695972 hasConcept C2911091166 @default.
• W2155695972 hasConcept C55493867 @default.
• W2155695972 hasConcept C62231903 @default.
• W2155695972 hasConcept C6997183 @default.
• W2155695972 hasConcept C71924100 @default.
• W2155695972 hasConcept C86803240 @default.
• W2155695972 hasConceptScore W2155695972C111133373 @default.
• W2155695972 hasConceptScore W2155695972C126322002 @default.
• W2155695972 hasConceptScore W2155695972C134018914 @default.
• W2155695972 hasConceptScore W2155695972C181199279 @default.
• W2155695972 hasConceptScore W2155695972C20251656 @default.
• W2155695972 hasConceptScore W2155695972C2777300911 @default.
• W2155695972 hasConceptScore W2155695972C2777318727 @default.
• W2155695972 hasConceptScore W2155695972C2778198053 @default.
• W2155695972 hasConceptScore W2155695972C2778849806 @default.
• W2155695972 hasConceptScore W2155695972C2779959927 @default.
• W2155695972 hasConceptScore W2155695972C2911091166 @default.
• W2155695972 hasConceptScore W2155695972C55493867 @default.
• W2155695972 hasConceptScore W2155695972C62231903 @default.
• W2155695972 hasConceptScore W2155695972C6997183 @default.
• W2155695972 hasConceptScore W2155695972C71924100 @default.
• W2155695972 hasConceptScore W2155695972C86803240 @default.
• W2155695972 hasIssue "1" @default.
• W2155695972 hasLocation W21556959721 @default.
• W2155695972 hasLocation W21556959722 @default.
• W2155695972 hasOpenAccess W2155695972 @default.
• W2155695972 hasPrimaryLocation W21556959721 @default.
• W2155695972 hasRelatedWork W1846146247 @default.

• next