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• W2155698747 endingPage "419" @default.
• W2155698747 startingPage "408" @default.
• W2155698747 abstract "Membrane transport processes, at both the plasma membranes and intracellular membranes, play critical roles in renal function and are a determining factor in the susceptibility of renal epithelial cells to blood-borne drugs and toxic chemicals. Proximal tubular epithelial cells possess a large array of transport proteins for organic anions, organic cations, and peptides on both basolateral and brush-border plasma membranes. Although these transporters function in excretion of waste products and reabsorption of nutrients, they also play a role in the susceptibility of the kidneys to drugs and other toxicants in the blood. The proximal tubules are typically the primary target cells because they are the first epithelial cell population exposed to such chemicals in either the renal plasma or glomerular filtrate and because of their large array of membrane transporters. Besides transport across the basolateral and brush-border plasma membranes, transport across intracellular membranes such as the mitochondrial inner membrane is a critical determinant of metabolite distribution. To illustrate the function of these transporters, carrier-mediated processes for transport of the tripeptide and antioxidant glutathione across the basolateral, brush-border, and mitochondrial inner membranes of the renal proximal tubule are reviewed. Studies are summarized that have identified the involvement of specific carrier proteins and characterized the role of these transporters in glutathione metabolism and turnover, susceptibility of the proximal tubules to oxidative and other stresses, and modulation in disease and other pathological processes." @default.
• W2155698747 created "2016-06-24" @default.
• W2155698747 creator A5076950649 @default.
• W2155698747 date "2010-07-23" @default.
• W2155698747 modified "2023-10-17" @default.
• W2155698747 title "Renal Membrane Transport of Glutathione in Toxicology and Disease" @default.
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• W2155698747 doi "https://doi.org/10.1177/0300985810375811" @default.
• W2155698747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20656901" @default.
• W2155698747 hasPublicationYear "2010" @default.
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