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• W2155698910 abstract "During embryonic development, the cerebral cortex attains its characteristic adult laminated structure. The finding that X-linked lissencephaly patients harbor mutations in the doublecortin gene implicated this gene product in the process of corticogenesis. An autosomal human gene, KIAA0369, with a high level of similarity to doublecortin, has been cloned from human adult brain. This gene product contains a kinase domain in addition to a doublecortin-like domain. In order to evaluate whether this doublecortin-like kinase also plays a role during brain development, we cloned and studied the expression pattern of the mouse homolog. Three cDNA products of this gene were cloned: one, doublecortin-like kinase, the second containing only the doublecortin-like region, and the third containing only the kinase domain, a homolog of the previously cloned rat CPG16 gene. We studied doublecortin-like kinase expression in mouse using Northern blot analysis, in situ hybridization, and Western blot analysis, and conclude that doublecortin-like kinase is expressed in multiple regions of embryonic brain including the developing cerebral cortex. J. Neurosci. Res. 58:567–575, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2155698910 date "1999-10-21" @default.
• W2155698910 modified "2023-09-26" @default.
• W2155698910 title "KIAA0369, doublecortin-like kinase, is expressed during brain development" @default.
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• W2155698910 doi "https://doi.org/10.1002/(sici)1097-4547(19991115)58:4<567::aid-jnr9>3.0.co;2-t" @default.
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