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- W2155698942 abstract "Multivolume 1 H-[ 13 C] NMR spectroscopy in combination with i.v. [1,6- 13 C 2 ]glucose infusion was used to detect regional glucose metabolism and glutamatergic neurotransmission in the halothane-anesthetized rat brain at 7 T. The regional information was decomposed into pure cerebral gray matter, white matter, and subcortical structures by means of tissue segmentation based on quantitative T 1 relaxation mapping. The 13 C turnover curves of [4- 13 C]glutamate, [4- 13 C]glutamine, and [3- 13 C]glutamate + glutamine were fitted with a two-compartment neuronal-astroglial metabolic model. The neuronal tricarboxylic acid cycle fluxes in cerebral gray matter, white matter, and subcortex were 0.79 ± 0.15, 0.20 ± 0.11, and 0.42 ± 0.09 μmol/min per g, respectively. The glutamate-glutamine neurotransmitter cycle fluxes in cerebral gray matter, white matter, and subcortex were 0.31 ± 0.07, 0.02 ± 0.04, and 0.18 ± 0.12 μmol/min per g, respectively. The exchange rate between the mitochondrial and cytosolic metabolite pools was fast relative to the neuronal tricarboxylic acid cycle flux for all cerebral tissue types." @default.
- W2155698942 created "2016-06-24" @default.
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- W2155698942 date "2004-08-13" @default.
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- W2155698942 title "Regional glucose metabolism and glutamatergic neurotransmission in rat brain <i>in vivo</i>" @default.
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- W2155698942 doi "https://doi.org/10.1073/pnas.0405065101" @default.
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