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- W2155703153 abstract "Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 microg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils." @default.
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- W2155703153 date "1999-02-01" @default.
- W2155703153 modified "2023-09-24" @default.
- W2155703153 title "The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas" @default.
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- W2155703153 doi "https://doi.org/10.1016/s0304-3835(98)00310-3" @default.
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