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- W2155705038 abstract "Selenomethionine, an amino acid occurring in proteins in place of methionine, reacts efficiently with oxidants, e.g., peroxynitrite, a biological oxidant generated in inflammatory states, to produce the oxidation product, methionine selenoxide. The present work describes the rapid and efficient reduction of the selenoxide to selenomethionine by glutathione in a stoichiometric reaction utilizing two equivalents of thiol. This nonenzymatic reaction establishes a defense line against peroxynitrite or other oxidants by selenomethionine residues in proteins, maintained by the ubiquitous thiol, glutathione." @default.
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- W2155705038 date "1998-01-01" @default.
- W2155705038 modified "2023-09-26" @default.
- W2155705038 title "Reduction of Methionine Selenoxide to Selenomethionine by Glutathione" @default.
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- W2155705038 doi "https://doi.org/10.1006/abbi.1997.0462" @default.
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