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- W2155736145 abstract "This study aimed to evaluate the expression level of runt-related transcription factor 3 (RUNX3) in human primary hepatocellular carcinomas (HCCs) and its relationship with the clinic pathological features.RUNX3 expression was analyzed by real-time fluorescent quantitative PCR, immunohistochemistry and Western blotting in HCC cells and tissues.RUNX3 RNA and protein expression was decreased in HCC tissues compared with the adjacent normal tissues (P< 0.001), mRNA frequently being down-regulated in HCC cell lines (66.67%, 4/6). Low expression of RUNX3 showed a significant correlation with cirrhosis (P = 0.028), histologic type (P = 0.000) and lymph node metastasis (P= 0.004).RUNX3 expression is deleted or decreased in HCCs and cell lines, in association with progression and prognosis." @default.
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- W2155736145 date "2011-01-01" @default.
- W2155736145 modified "2023-09-27" @default.
- W2155736145 title "Loss of runt-related transcription factor 3 expression associated with human hepatocellular carcinoma progression and prognosis." @default.
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