FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155753151> ?p ?o ?g. }

• W2155753151 abstract "Infection is a major cause of mortality in the first year following single lung transplantation and is a distinct risk factor for the development of obliterative bronchiolitis. However, little is known about changes in pulmonary vascular activity in the setting of infection, which might affect and limit function of the graft. Therefore, the aim of this study was to determine how acute infection altered pulmonary arterial reactivity in single lung allografts. Such information could help to develop better diagnostic and therapeutic targets to improve outcome when grafts become infected.Following single lung transplantation, dogs were immunosuppressed with methylprednisolone acetate, cyclosporine and azathioprine. On postoperative day 5, infection was induced in one group of dogs by endobronchial inoculation of antibiotic resistant Eschericia coli (infection group, n=5); in the second group, the same amount of culture media without bacteria was flushed into the bronchus (control group, n=4). All animals were medicated under the same drug protocol. On postoperative day 8, lungs were removed, reviewed for histological assessment, pulmonary arteries were isolated, cut into rings and suspended for pharmacological characterization in organ chambers.With acute infections, contractions to phenylephrine and angiotensin-1, but not endothelin-1, were reduced in pulmonary arteries with but not without endothelium. Inhibition of nitric oxide synthase with N(G)-monomethyl-L-arginine, monoacetate salt (L-NMMA) restored these contractions. Endothelium-dependent relaxations to adenosine diphosphate and calcium ionophore, which stimulate release of endothelium-derived nitric oxide by a receptor and non-receptor mediated process, respectively, were not different between groups. Relaxations to nitric oxide also were not different between groups.These results suggest that acute infection selectively reduces contractions of pulmonary arteries in part through receptor-mediated release of nitric oxide from the endothelium. Inhibiting nitric oxide during episodes of acute infection may help to improve graft perfusion during episodes of acute infection." @default.
• W2155753151 created "2016-06-24" @default.
• W2155753151 creator A5026874845 @default.
• W2155753151 creator A5040832215 @default.
• W2155753151 creator A5043106168 @default.
• W2155753151 creator A5043898438 @default.
• W2155753151 creator A5071847625 @default.
• W2155753151 creator A5077814849 @default.
• W2155753151 date "2007-03-01" @default.
• W2155753151 modified "2023-10-08" @default.
• W2155753151 title "Pulmonary arterial reactivity during induced infection of single lung allografts☆" @default.
• W2155753151 cites W1513486408 @default.
• W2155753151 cites W1970617808 @default.
• W2155753151 cites W1972473400 @default.
• W2155753151 cites W1984571968 @default.
• W2155753151 cites W1995479074 @default.
• W2155753151 cites W1997098181 @default.
• W2155753151 cites W2005940148 @default.
• W2155753151 cites W2024683832 @default.
• W2155753151 cites W2035650094 @default.
• W2155753151 cites W2036238654 @default.
• W2155753151 cites W2052029498 @default.
• W2155753151 cites W2068469411 @default.
• W2155753151 cites W2072275397 @default.
• W2155753151 cites W2078824073 @default.
• W2155753151 cites W2085461684 @default.
• W2155753151 cites W2110902457 @default.
• W2155753151 cites W2143677229 @default.
• W2155753151 cites W2165069134 @default.
• W2155753151 cites W2262997450 @default.
• W2155753151 cites W2411694852 @default.
• W2155753151 cites W2416921937 @default.
• W2155753151 cites W2798800755 @default.
• W2155753151 cites W293256224 @default.
• W2155753151 cites W7885730 @default.
• W2155753151 doi "https://doi.org/10.1016/j.ejcts.2006.11.051" @default.
• W2155753151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17212984" @default.
• W2155753151 hasPublicationYear "2007" @default.
• W2155753151 type Work @default.
• W2155753151 sameAs 2155753151 @default.
• W2155753151 citedByCount "1" @default.
• W2155753151 countsByYear W21557531512013 @default.
• W2155753151 crossrefType "journal-article" @default.
• W2155753151 hasAuthorship W2155753151A5026874845 @default.
• W2155753151 hasAuthorship W2155753151A5040832215 @default.
• W2155753151 hasAuthorship W2155753151A5043106168 @default.
• W2155753151 hasAuthorship W2155753151A5043898438 @default.
• W2155753151 hasAuthorship W2155753151A5071847625 @default.
• W2155753151 hasAuthorship W2155753151A5077814849 @default.
• W2155753151 hasBestOaLocation W21557531511 @default.
• W2155753151 hasConcept C126322002 @default.
• W2155753151 hasConcept C144980905 @default.
• W2155753151 hasConcept C170493617 @default.
• W2155753151 hasConcept C2776992346 @default.
• W2155753151 hasConcept C2777714996 @default.
• W2155753151 hasConcept C2780930700 @default.
• W2155753151 hasConcept C2780940725 @default.
• W2155753151 hasConcept C2781448352 @default.
• W2155753151 hasConcept C2911091166 @default.
• W2155753151 hasConcept C42219234 @default.
• W2155753151 hasConcept C519581460 @default.
• W2155753151 hasConcept C71924100 @default.
• W2155753151 hasConcept C98274493 @default.
• W2155753151 hasConceptScore W2155753151C126322002 @default.
• W2155753151 hasConceptScore W2155753151C144980905 @default.
• W2155753151 hasConceptScore W2155753151C170493617 @default.
• W2155753151 hasConceptScore W2155753151C2776992346 @default.
• W2155753151 hasConceptScore W2155753151C2777714996 @default.
• W2155753151 hasConceptScore W2155753151C2780930700 @default.
• W2155753151 hasConceptScore W2155753151C2780940725 @default.
• W2155753151 hasConceptScore W2155753151C2781448352 @default.
• W2155753151 hasConceptScore W2155753151C2911091166 @default.
• W2155753151 hasConceptScore W2155753151C42219234 @default.
• W2155753151 hasConceptScore W2155753151C519581460 @default.
• W2155753151 hasConceptScore W2155753151C71924100 @default.
• W2155753151 hasConceptScore W2155753151C98274493 @default.
• W2155753151 hasLocation W21557531511 @default.
• W2155753151 hasLocation W21557531512 @default.
• W2155753151 hasOpenAccess W2155753151 @default.
• W2155753151 hasPrimaryLocation W21557531511 @default.
• W2155753151 hasRelatedWork W130374736 @default.
• W2155753151 hasRelatedWork W2044327891 @default.
• W2155753151 hasRelatedWork W2095074620 @default.
• W2155753151 hasRelatedWork W2132358994 @default.
• W2155753151 hasRelatedWork W2155082817 @default.
• W2155753151 hasRelatedWork W2294597690 @default.
• W2155753151 hasRelatedWork W2338301107 @default.
• W2155753151 hasRelatedWork W2430168491 @default.
• W2155753151 hasRelatedWork W3000662210 @default.
• W2155753151 hasRelatedWork W4281756855 @default.
• W2155753151 isParatext "false" @default.
• W2155753151 isRetracted "false" @default.
• W2155753151 magId "2155753151" @default.
• W2155753151 workType "article" @default.