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- W2155754186 abstract "In pocket: A new class of potent inhibitors of factor Xa features a quaternary ammonium ion to fill the aromatic box in the S4 pocket and a 2-chlorothiophenyl group to occupy the S1 pocket (see picture; red O, blue N, yellow S, green Cl). Changing from a primary to a quaternary ammonium ion increases the binding affinity by a factor of 1000. The poor affinity in the former case suggests negligible cation–π interactions between Lys and Trp." @default.
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- W2155754186 date "2009-01-05" @default.
- W2155754186 modified "2023-10-13" @default.
- W2155754186 title "Cation–π Interactions at the Active Site of Factor Xa: Dramatic Enhancement upon Stepwise N‐Alkylation of Ammonium Ions" @default.
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- W2155754186 doi "https://doi.org/10.1002/anie.200804695" @default.
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