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- W2155759872 endingPage "87" @default.
- W2155759872 startingPage "63" @default.
- W2155759872 abstract "Chronic pancreatitis (CP) is a persistent inflammation of the pancreas. Over the past 12 years, genetic studies of hereditary, familial, and idiopathic forms of CP have made great progress in defining the disease pathogenesis. Identification of gain-of-function missense and copy number mutations in the cationic trypsinogen gene (PRSS1) and loss-of-function variants in both the pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) genes has firmly established the pivotal role of prematurely activated trypsin within the pancreas in the etiology of CP. Loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-sensing receptor (CASR) genes also increase the risk of CP. Here, we review recent developments in this rapidly evolving field, highlight the importance of gene-gene and gene-environment interactions in causing the disease, and discuss the opportunities and challenges in identifying novel genetic factors that affect susceptibility/resistance to CP." @default.
- W2155759872 created "2016-06-24" @default.
- W2155759872 creator A5024873764 @default.
- W2155759872 creator A5066521398 @default.
- W2155759872 date "2009-09-01" @default.
- W2155759872 modified "2023-10-18" @default.
- W2155759872 title "Chronic Pancreatitis: Genetics and Pathogenesis" @default.
- W2155759872 cites W135364694 @default.
- W2155759872 cites W1527125614 @default.
- W2155759872 cites W1563800735 @default.
- W2155759872 cites W1689369637 @default.
- W2155759872 cites W1796562174 @default.
- W2155759872 cites W1843267607 @default.
- W2155759872 cites W1870094350 @default.
- W2155759872 cites W189405811 @default.
- W2155759872 cites W1964910827 @default.
- W2155759872 cites W1965444834 @default.
- W2155759872 cites W1965554871 @default.
- W2155759872 cites W1966538429 @default.
- W2155759872 cites W1968862068 @default.
- W2155759872 cites W1971032058 @default.
- W2155759872 cites W1972147587 @default.
- W2155759872 cites W1972570834 @default.
- W2155759872 cites W1972579181 @default.
- W2155759872 cites W1973140084 @default.
- W2155759872 cites W1973778543 @default.
- W2155759872 cites W1974427864 @default.
- W2155759872 cites W1976211445 @default.
- W2155759872 cites W1977157373 @default.
- W2155759872 cites W1979187485 @default.
- W2155759872 cites W1983542077 @default.
- W2155759872 cites W1984013822 @default.
- W2155759872 cites W1984585928 @default.
- W2155759872 cites W1985300710 @default.
- W2155759872 cites W1987506516 @default.
- W2155759872 cites W1989769122 @default.
- W2155759872 cites W1990388763 @default.
- W2155759872 cites W1990814447 @default.
- W2155759872 cites W1991643179 @default.
- W2155759872 cites W1992145934 @default.
- W2155759872 cites W1992247319 @default.
- W2155759872 cites W1993211081 @default.
- W2155759872 cites W1994986431 @default.
- W2155759872 cites W1995445640 @default.
- W2155759872 cites W1995518601 @default.
- W2155759872 cites W1997649040 @default.
- W2155759872 cites W1997718215 @default.
- W2155759872 cites W1999840642 @default.
- W2155759872 cites W2006590632 @default.
- W2155759872 cites W2009132217 @default.
- W2155759872 cites W2010378709 @default.
- W2155759872 cites W2012516045 @default.
- W2155759872 cites W2013458238 @default.
- W2155759872 cites W2014389163 @default.
- W2155759872 cites W2014903057 @default.
- W2155759872 cites W2015849111 @default.
- W2155759872 cites W2016899885 @default.
- W2155759872 cites W2017183042 @default.
- W2155759872 cites W2019855088 @default.
- W2155759872 cites W2020259164 @default.
- W2155759872 cites W2021717992 @default.
- W2155759872 cites W2024369834 @default.
- W2155759872 cites W2027484282 @default.
- W2155759872 cites W2028307216 @default.
- W2155759872 cites W2029904363 @default.
- W2155759872 cites W2032068101 @default.
- W2155759872 cites W2033780498 @default.
- W2155759872 cites W2033797870 @default.
- W2155759872 cites W2034421470 @default.
- W2155759872 cites W2038802602 @default.
- W2155759872 cites W2039551140 @default.
- W2155759872 cites W2039599894 @default.
- W2155759872 cites W2041031378 @default.
- W2155759872 cites W2042784854 @default.
- W2155759872 cites W2043935974 @default.
- W2155759872 cites W2045322786 @default.
- W2155759872 cites W2054718401 @default.
- W2155759872 cites W2057988159 @default.
- W2155759872 cites W2060007848 @default.
- W2155759872 cites W2061095913 @default.
- W2155759872 cites W2061413691 @default.
- W2155759872 cites W2062292356 @default.
- W2155759872 cites W2062676147 @default.
- W2155759872 cites W2067080189 @default.
- W2155759872 cites W2067754875 @default.
- W2155759872 cites W2072477333 @default.
- W2155759872 cites W2073024525 @default.
- W2155759872 cites W2078663610 @default.
- W2155759872 cites W2079410407 @default.
- W2155759872 cites W2080871465 @default.
- W2155759872 cites W2083214486 @default.
- W2155759872 cites W2085404502 @default.
- W2155759872 cites W2086015868 @default.
- W2155759872 cites W2086741871 @default.
- W2155759872 cites W2086794332 @default.
- W2155759872 cites W2087266225 @default.
- W2155759872 cites W2087735740 @default.
- W2155759872 cites W2089198803 @default.