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• W2155778913 abstract "Object Magnetic resonance (MR) imaging now permits diagnosis of increasing numbers of small, minimally symptomatic vestibular schwannomas (VSs). Because VS growth patterns over time are very important in refining treatment strategies, these matters were systematically reviewed. Methods An extensive MEDLINE search was performed to cull studies on VS growth according to sequential imaging. The percentages of growing and regressing tumors and lesions requiring treatment during follow-up periods were calculated. Factors associated with differences among studies were identified. Twenty-six studies including 1340 patients met all inclusion criteria. The overall frequency of VS growth during a mean follow-up period of 38 months was 46% (95% confidence interval [CI] 43–48%) and that of regression was 8% (95% CI 6–10%). The mean annual tumor growth rate was 1.2 mm/year. Furthermore, the percentage of cases requiring treatment during follow up was 18% (95% CI 16–21%). According to results of a sensitivity analysis, evaluation by serial MR imaging (39%, 95% CI 35–43%) and a prospective study design (29%, 95% CI 21–37%) were associated with less frequent reported tumor growth. Conclusions Although their applicability may be limited to relatively elderly patients with small tumors, data revealing a limited frequency of VS enlargement and an infrequent necessity for eventual therapy should assist decision-making in the treatment of small VSs causing minimal symptoms." @default.
• W2155778913 created "2016-06-24" @default.
• W2155778913 creator A5045165973 @default.
• W2155778913 date "2005-07-01" @default.
• W2155778913 modified "2023-09-27" @default.
• W2155778913 title "Systematic review of the natural history of vestibular schwannoma" @default.
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• W2155778913 doi "https://doi.org/10.3171/jns.2005.103.1.0059" @default.
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