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- W2155785853 startingPage "351" @default.
- W2155785853 abstract "This chapter describes the in vitro assay for transfer factor (TF) using direct migration inhibition. The effect of transfer factor prepared from tuberculin-positive individuals on the migration of leukocytes from tuberculin-negative subjects in the presence of BCG is examined. For these experiments, whole cell lysates, treated with RNase and DNase were used and resulted in significant inhibition of migration of cells from tuberculin negative individuals. TF prepared by conventional techniques for in vivo use also caused inhibition of direct migration inhibition system (DMI), but seemed to be less effective than the whole cell lysate. The effect of this lysate on four tuberculin-negative individuals is shown. None of the four individuals showed significant inhibition to BCG alone. In the presence of the TF preparation, there was an increase in inhibition ranging from 16% to 34%. The DMI of leukocytes from tuberculin-negative recipient SS showed no increased inhibition to BCG in the presence of the two TF preparations from tuberculin-negative donors. Significant inhibition was observed when the positive TF preparations were used." @default.
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- W2155785853 date "1965-10-01" @default.
- W2155785853 modified "2023-09-25" @default.
- W2155785853 title "The Prospective Use of BGC and Isoniazid Chemoprophylaxis in Prevention of Tuberculosis in Developed and Developing Countries *" @default.
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- W2155785853 doi "https://doi.org/10.1378/chest.48.4.351" @default.
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