FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155791288> ?p ?o ?g. }

• W2155791288 endingPage "97" @default.
• W2155791288 startingPage "92" @default.
• W2155791288 abstract "It has become apparent that hypoxia and hypoxia-inducible factor-1 (HIF-1) activation have the potential of modulating the activity of major epithelial-mesenchymal transition (EMT)-triggering pathways by regulating the expression and activity levels of major transcriptional repressors. The aim of our study was to elucidate the role of HIF-1α and HIF-2α, and EMT regulators TWIST2 and SMAD nuclear interacting protein-1 (SNIP1) in tongue squamous cell carcinoma (TSCC). A retrospective analysis of 89 patients with TSCC from Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 2002 and 2005 was performed using immunohistochemistry in paraffin-embedded and formalin-fixed tissues to analyze HIF-1α, HIF-2α, TWIST2 and SNIP1 expression. The association between HIF-1α, HIF-2α, TWIST2 and SNIP1 expression and patient survivals was investigated. Our results showed that overexpression of HIF-1α, HIF-2α, TWIST2 and SNIP1 were shown in 49.44% (44/89), 55.06% (49/89), 44.94% (40/89) and 34.83% (31/89) of TSCC, respectively. Overexpression of HIF-1α, TWIST2 and SNIP1 in TSCC was associated with a shorter disease-free survival (P=0.003, P=0.001, P=0.040, respectively), and HIF-2α had no significant association with either overall survival (P=0.195) or disease-free survival (P=0.356). Co-expression of more than two markers of HIF-1α, TWIST2 and SNIP1 was an independent prognostic indicator for both overall survival and disease-free survival by multivariate Cox proportional hazards model. It is proposed that co-expression of more than two markers from HIF-1α, TWIST2 and SNIP1 might be a significant prognostic predictor in patients with TSCC." @default.
• W2155791288 created "2016-06-24" @default.
• W2155791288 creator A5000700564 @default.
• W2155791288 creator A5002325550 @default.
• W2155791288 creator A5055376209 @default.
• W2155791288 creator A5063812121 @default.
• W2155791288 creator A5082323158 @default.
• W2155791288 creator A5086902278 @default.
• W2155791288 date "2011-02-01" @default.
• W2155791288 modified "2023-10-12" @default.
• W2155791288 title "Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma" @default.
• W2155791288 cites W1578920942 @default.
• W2155791288 cites W1855322575 @default.
• W2155791288 cites W1965255998 @default.
• W2155791288 cites W1967042873 @default.
• W2155791288 cites W1970744454 @default.
• W2155791288 cites W1987318948 @default.
• W2155791288 cites W1996488211 @default.
• W2155791288 cites W2003602667 @default.
• W2155791288 cites W2016353415 @default.
• W2155791288 cites W2024334459 @default.
• W2155791288 cites W2025486904 @default.
• W2155791288 cites W2025647419 @default.
• W2155791288 cites W2036008499 @default.
• W2155791288 cites W2036022656 @default.
• W2155791288 cites W2050459519 @default.
• W2155791288 cites W2053880555 @default.
• W2155791288 cites W2054974538 @default.
• W2155791288 cites W2059372860 @default.
• W2155791288 cites W2063011414 @default.
• W2155791288 cites W2071609983 @default.
• W2155791288 cites W2081199472 @default.
• W2155791288 cites W2082496912 @default.
• W2155791288 cites W2122523158 @default.
• W2155791288 cites W2128961172 @default.
• W2155791288 cites W2131718664 @default.
• W2155791288 cites W2134361367 @default.
• W2155791288 cites W2142982924 @default.
• W2155791288 cites W2153223436 @default.
• W2155791288 cites W2045181115 @default.
• W2155791288 doi "https://doi.org/10.1016/j.oraloncology.2010.11.014" @default.
• W2155791288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167768" @default.
• W2155791288 hasPublicationYear "2011" @default.
• W2155791288 type Work @default.
• W2155791288 sameAs 2155791288 @default.
• W2155791288 citedByCount "68" @default.
• W2155791288 countsByYear W21557912882012 @default.
• W2155791288 countsByYear W21557912882013 @default.
• W2155791288 countsByYear W21557912882014 @default.
• W2155791288 countsByYear W21557912882015 @default.
• W2155791288 countsByYear W21557912882016 @default.
• W2155791288 countsByYear W21557912882017 @default.
• W2155791288 countsByYear W21557912882018 @default.
• W2155791288 countsByYear W21557912882019 @default.
• W2155791288 countsByYear W21557912882020 @default.
• W2155791288 countsByYear W21557912882021 @default.
• W2155791288 countsByYear W21557912882023 @default.
• W2155791288 crossrefType "journal-article" @default.
• W2155791288 hasAuthorship W2155791288A5000700564 @default.
• W2155791288 hasAuthorship W2155791288A5002325550 @default.
• W2155791288 hasAuthorship W2155791288A5055376209 @default.
• W2155791288 hasAuthorship W2155791288A5063812121 @default.
• W2155791288 hasAuthorship W2155791288A5082323158 @default.
• W2155791288 hasAuthorship W2155791288A5086902278 @default.
• W2155791288 hasConcept C104317684 @default.
• W2155791288 hasConcept C10515644 @default.
• W2155791288 hasConcept C121608353 @default.
• W2155791288 hasConcept C126322002 @default.
• W2155791288 hasConcept C142724271 @default.
• W2155791288 hasConcept C143998085 @default.
• W2155791288 hasConcept C178790620 @default.
• W2155791288 hasConcept C185592680 @default.
• W2155791288 hasConcept C204232928 @default.
• W2155791288 hasConcept C2779013556 @default.
• W2155791288 hasConcept C2780394083 @default.
• W2155791288 hasConcept C31194975 @default.
• W2155791288 hasConcept C502942594 @default.
• W2155791288 hasConcept C50382708 @default.
• W2155791288 hasConcept C540031477 @default.
• W2155791288 hasConcept C55493867 @default.
• W2155791288 hasConcept C71924100 @default.
• W2155791288 hasConcept C76419328 @default.
• W2155791288 hasConcept C7836513 @default.
• W2155791288 hasConcept C86339819 @default.
• W2155791288 hasConcept C86803240 @default.
• W2155791288 hasConceptScore W2155791288C104317684 @default.
• W2155791288 hasConceptScore W2155791288C10515644 @default.
• W2155791288 hasConceptScore W2155791288C121608353 @default.
• W2155791288 hasConceptScore W2155791288C126322002 @default.
• W2155791288 hasConceptScore W2155791288C142724271 @default.
• W2155791288 hasConceptScore W2155791288C143998085 @default.
• W2155791288 hasConceptScore W2155791288C178790620 @default.
• W2155791288 hasConceptScore W2155791288C185592680 @default.
• W2155791288 hasConceptScore W2155791288C204232928 @default.
• W2155791288 hasConceptScore W2155791288C2779013556 @default.
• W2155791288 hasConceptScore W2155791288C2780394083 @default.
• W2155791288 hasConceptScore W2155791288C31194975 @default.
• W2155791288 hasConceptScore W2155791288C502942594 @default.

• next