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• W2155796970 abstract "ABSTRACT Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD- scid IL2Rγ null mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD- scid β2microglobulin null mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc 1 ." @default.
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• W2155796970 date "2009-10-01" @default.
• W2155796970 modified "2023-10-18" @default.
• W2155796970 title "Improved Murine Model of Malaria Using<i>Plasmodium falciparum</i>Competent Strains and Non-Myelodepleted NOD-<i>scid IL2R</i>γ^<i>null</i>Mice Engrafted with Human Erythrocytes" @default.
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• W2155796970 doi "https://doi.org/10.1128/aac.00519-09" @default.
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