Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155803210> ?p ?o ?g. }
- W2155803210 endingPage "1723" @default.
- W2155803210 startingPage "1712" @default.
- W2155803210 abstract "Telomere mutants have been well studied with respect to telomerase and the role of telomere binding proteins, but they have not been used to explore how a downstream morphogenic event is related to the mutated telomeric DNA. We report that alterations at the telomeres can have profound consequences on organellar morphogenesis. Specifically, a telomerase RNA mutation termed ter1-43AA results in the loss of germ line micronuclear telomeres in the binucleate protozoan Tetrahymena thermophila. These cells also display a micronuclear mitotic arrest, characterized by an extreme delay in anaphase with an elongated, condensed chromatin and a mitotic spindle apparatus. This anaphase defect suggests telomere fusions and consequently a spindle rather than a DNA damage checkpoint. Most surprisingly, these mutants exhibit unique, dramatic defects in the formation of the cell's oral apparatus. We suggest that micronuclear telomere loss leads to a dynamic pause in the program of cortical development, which may reveal an unusual cell cycle checkpoint." @default.
- W2155803210 created "2016-06-24" @default.
- W2155803210 creator A5000782383 @default.
- W2155803210 creator A5001863290 @default.
- W2155803210 creator A5051817030 @default.
- W2155803210 creator A5058189853 @default.
- W2155803210 creator A5077299435 @default.
- W2155803210 creator A5087452322 @default.
- W2155803210 creator A5057799915 @default.
- W2155803210 date "2008-10-01" @default.
- W2155803210 modified "2023-10-18" @default.
- W2155803210 title "Abnormal Micronuclear Telomeres Lead to an Unusual Cell Cycle Checkpoint and Defects in <i>Tetrahymena</i> Oral Morphogenesis" @default.
- W2155803210 cites W1543500873 @default.
- W2155803210 cites W1563912073 @default.
- W2155803210 cites W1567895573 @default.
- W2155803210 cites W1593815359 @default.
- W2155803210 cites W1600507651 @default.
- W2155803210 cites W176521956 @default.
- W2155803210 cites W1829553711 @default.
- W2155803210 cites W1926599286 @default.
- W2155803210 cites W1975716080 @default.
- W2155803210 cites W1980698422 @default.
- W2155803210 cites W1992690684 @default.
- W2155803210 cites W1998446391 @default.
- W2155803210 cites W2004129040 @default.
- W2155803210 cites W2013915975 @default.
- W2155803210 cites W2024776125 @default.
- W2155803210 cites W203551320 @default.
- W2155803210 cites W2035931727 @default.
- W2155803210 cites W2039316599 @default.
- W2155803210 cites W2045067357 @default.
- W2155803210 cites W2052008018 @default.
- W2155803210 cites W2055546821 @default.
- W2155803210 cites W2065117415 @default.
- W2155803210 cites W2069169350 @default.
- W2155803210 cites W2077449437 @default.
- W2155803210 cites W2082941148 @default.
- W2155803210 cites W2083168268 @default.
- W2155803210 cites W2085507237 @default.
- W2155803210 cites W2088512897 @default.
- W2155803210 cites W2092446580 @default.
- W2155803210 cites W2096652477 @default.
- W2155803210 cites W2106311785 @default.
- W2155803210 cites W2108175136 @default.
- W2155803210 cites W2111922126 @default.
- W2155803210 cites W2118219279 @default.
- W2155803210 cites W2131104199 @default.
- W2155803210 cites W2137005928 @default.
- W2155803210 cites W2137889806 @default.
- W2155803210 cites W2142298035 @default.
- W2155803210 cites W2151374838 @default.
- W2155803210 cites W2166525605 @default.
- W2155803210 cites W2175750849 @default.
- W2155803210 doi "https://doi.org/10.1128/ec.00393-07" @default.
- W2155803210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568063" @default.
- W2155803210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18469136" @default.
- W2155803210 hasPublicationYear "2008" @default.
- W2155803210 type Work @default.
- W2155803210 sameAs 2155803210 @default.
- W2155803210 citedByCount "8" @default.
- W2155803210 countsByYear W21558032102012 @default.
- W2155803210 countsByYear W21558032102014 @default.
- W2155803210 countsByYear W21558032102022 @default.
- W2155803210 crossrefType "journal-article" @default.
- W2155803210 hasAuthorship W2155803210A5000782383 @default.
- W2155803210 hasAuthorship W2155803210A5001863290 @default.
- W2155803210 hasAuthorship W2155803210A5051817030 @default.
- W2155803210 hasAuthorship W2155803210A5057799915 @default.
- W2155803210 hasAuthorship W2155803210A5058189853 @default.
- W2155803210 hasAuthorship W2155803210A5077299435 @default.
- W2155803210 hasAuthorship W2155803210A5087452322 @default.
- W2155803210 hasBestOaLocation W21558032102 @default.
- W2155803210 hasConcept C104317684 @default.
- W2155803210 hasConcept C105696609 @default.
- W2155803210 hasConcept C143065580 @default.
- W2155803210 hasConcept C1491633281 @default.
- W2155803210 hasConcept C177336024 @default.
- W2155803210 hasConcept C186000732 @default.
- W2155803210 hasConcept C2777166614 @default.
- W2155803210 hasConcept C29537977 @default.
- W2155803210 hasConcept C53420372 @default.
- W2155803210 hasConcept C54086632 @default.
- W2155803210 hasConcept C54355233 @default.
- W2155803210 hasConcept C552990157 @default.
- W2155803210 hasConcept C83640560 @default.
- W2155803210 hasConcept C86803240 @default.
- W2155803210 hasConcept C93304396 @default.
- W2155803210 hasConcept C94581717 @default.
- W2155803210 hasConcept C95444343 @default.
- W2155803210 hasConceptScore W2155803210C104317684 @default.
- W2155803210 hasConceptScore W2155803210C105696609 @default.
- W2155803210 hasConceptScore W2155803210C143065580 @default.
- W2155803210 hasConceptScore W2155803210C1491633281 @default.
- W2155803210 hasConceptScore W2155803210C177336024 @default.
- W2155803210 hasConceptScore W2155803210C186000732 @default.
- W2155803210 hasConceptScore W2155803210C2777166614 @default.
- W2155803210 hasConceptScore W2155803210C29537977 @default.
- W2155803210 hasConceptScore W2155803210C53420372 @default.