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• W2155803282 abstract "While prostaglandin production by uterine tissue has been shown to be involved in the contractile mechanism of this tissue, less attention has focused upon the involvement of other prostanoids. We have simultaneously measured in vitro isometric contractility of pregnant rat uteri with the release of prostaglandin F2α (PGF), 6-keto-prostaglandin F1α (6-k-PGF1α) and thromboxane B2 (TXB2) into the bathing medium under various conditions. Frequency of uterine contractions and integrated contractile force (ICF) increased from 15 days of gestation and peaked at the time of parturition. Activity was generally greatest during the first 15 min of incubation except during parturition and on Day 1 postpartum when the uterine segment remained active for 1 h experimental period. Indomethacin (INDO) significantly reduced contractile activity regardless of gestational stage. PGF, TXB2, and 6-k-PGF1α increased with gestational age, peaking at the time of parturition. Production was greatest during the first 15 min of incubation and INDO inhibited production of each prostanoid regardless of gestational stage. Imidazole (100 μg/ml) inhibited TXB2 production without affecting PGF or 6-k-PGF1α levels. Frequency of contraction and ICF were not affected by imidazole treatment despite TXB2 reduction. These data demonstrate that the in vitro uterus from pregnant rats is capable of producing prostanoids other than prostaglandins and their production generally parallels uterine contractile activity. Thus, the possibility that these prostanoids are involved in physiologic changes during parturition warrants further investigation." @default.
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• W2155803282 date "1982-03-01" @default.
• W2155803282 modified "2023-10-13" @default.
• W2155803282 title "Thromboxane B2, 6-Keto-Prostaglandin F1α, and Prostaglandin F2α Production by Contracting Pregnant Rat Uteri In Vitro" @default.
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• W2155803282 doi "https://doi.org/10.1095/biolreprod26.2.281" @default.
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