Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155803301> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2155803301 endingPage "97" @default.
- W2155803301 startingPage "92" @default.
- W2155803301 abstract "Prostatic intraepithelial neoplasia (PIN) is the most likely precursor of human prostate cancer. The prevalence and immunophenotype of PIN in dogs with spontaneous prostate cancer has not been previously described. To investigate the association between PIN and prostate cancer, we evaluated the prostates of dogs with spontaneous prostate carcinoma. The prevalence of PIN was determined in formalin-fixed prostates from 29 dogs with spontaneous prostate cancer. Using immunoperoxidase techniques, we compared basal cell layer integrity (high molecular weight keratin 34 beta-E12), proliferative index (MIB-1), and microvessel density (Factor VIII-related antigen) in 14 prostates which contained benign epithelium, PIN, and carcinoma. PIN was present in 19 of 29 (66%) prostates from dogs with spontaneous prostate cancer. The basal cell layer was intact in benign epithelium, disrupted in 72% of acini with PIN, and absent in carcinoma. The mean proliferative index was 17%, 25%, and 40% for benign epithelium, PIN, and carcinoma, respectively, and these differences were significant. The mean microvessel density in foci of PIN and carcinoma (32 and 39 vessels per mm2, respectively) was greater than in benign epithelium (23 vessels per mm2). High-grade PIN is common in the prostates of dogs with spontaneous carcinoma. The basal cell layer is partially disrupted in PIN, whereas it is absent in prostate cancer. The proliferative index and microvessel density of PIN are intermediate between benign epithelium and cancer. These results are similar to those reported for human PIN and prostate cancer, and indicate that PIN is part of a morphologic continuum in the progression of prostate cancer. To our knowledge, this is the first description of high-grade PIN spontaneously occurring in animals. The canine prostate may serve as a useful model for examining factors that modulate PIN and prostate cancer progression. Prostate 30:92–97, 1997. © 1997 Wiley-Liss, Inc." @default.
- W2155803301 created "2016-06-24" @default.
- W2155803301 creator A5004475698 @default.
- W2155803301 creator A5028171322 @default.
- W2155803301 creator A5039930530 @default.
- W2155803301 creator A5041766764 @default.
- W2155803301 creator A5048482314 @default.
- W2155803301 creator A5058714186 @default.
- W2155803301 date "1997-02-01" @default.
- W2155803301 modified "2023-09-27" @default.
- W2155803301 title "Prostatic intraepithelial neoplasia in dogs with spontaneous prostate cancer" @default.
- W2155803301 cites W117358055 @default.
- W2155803301 cites W1814602830 @default.
- W2155803301 cites W1971323327 @default.
- W2155803301 cites W1980977659 @default.
- W2155803301 cites W2018596412 @default.
- W2155803301 cites W2025149387 @default.
- W2155803301 cites W2027669169 @default.
- W2155803301 cites W2029575393 @default.
- W2155803301 cites W2030939881 @default.
- W2155803301 cites W2044075040 @default.
- W2155803301 cites W2045225395 @default.
- W2155803301 cites W2067824664 @default.
- W2155803301 cites W2068825839 @default.
- W2155803301 cites W2084197013 @default.
- W2155803301 cites W2093697115 @default.
- W2155803301 cites W2157104106 @default.
- W2155803301 cites W2396068614 @default.
- W2155803301 doi "https://doi.org/10.1002/(sici)1097-0045(19970201)30:2<92::aid-pros4>3.0.co;2-m" @default.
- W2155803301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9051147" @default.
- W2155803301 hasPublicationYear "1997" @default.
- W2155803301 type Work @default.
- W2155803301 sameAs 2155803301 @default.
- W2155803301 citedByCount "56" @default.
- W2155803301 countsByYear W21558033012012 @default.
- W2155803301 countsByYear W21558033012013 @default.
- W2155803301 countsByYear W21558033012014 @default.
- W2155803301 countsByYear W21558033012017 @default.
- W2155803301 countsByYear W21558033012019 @default.
- W2155803301 countsByYear W21558033012021 @default.
- W2155803301 countsByYear W21558033012022 @default.
- W2155803301 countsByYear W21558033012023 @default.
- W2155803301 crossrefType "journal-article" @default.
- W2155803301 hasAuthorship W2155803301A5004475698 @default.
- W2155803301 hasAuthorship W2155803301A5028171322 @default.
- W2155803301 hasAuthorship W2155803301A5039930530 @default.
- W2155803301 hasAuthorship W2155803301A5041766764 @default.
- W2155803301 hasAuthorship W2155803301A5048482314 @default.
- W2155803301 hasAuthorship W2155803301A5058714186 @default.
- W2155803301 hasConcept C121608353 @default.
- W2155803301 hasConcept C126322002 @default.
- W2155803301 hasConcept C142724271 @default.
- W2155803301 hasConcept C204232928 @default.
- W2155803301 hasConcept C2776235491 @default.
- W2155803301 hasConcept C2776436680 @default.
- W2155803301 hasConcept C2776456063 @default.
- W2155803301 hasConcept C2777546739 @default.
- W2155803301 hasConcept C2779534503 @default.
- W2155803301 hasConcept C2780192828 @default.
- W2155803301 hasConcept C529295009 @default.
- W2155803301 hasConcept C71924100 @default.
- W2155803301 hasConceptScore W2155803301C121608353 @default.
- W2155803301 hasConceptScore W2155803301C126322002 @default.
- W2155803301 hasConceptScore W2155803301C142724271 @default.
- W2155803301 hasConceptScore W2155803301C204232928 @default.
- W2155803301 hasConceptScore W2155803301C2776235491 @default.
- W2155803301 hasConceptScore W2155803301C2776436680 @default.
- W2155803301 hasConceptScore W2155803301C2776456063 @default.
- W2155803301 hasConceptScore W2155803301C2777546739 @default.
- W2155803301 hasConceptScore W2155803301C2779534503 @default.
- W2155803301 hasConceptScore W2155803301C2780192828 @default.
- W2155803301 hasConceptScore W2155803301C529295009 @default.
- W2155803301 hasConceptScore W2155803301C71924100 @default.
- W2155803301 hasIssue "2" @default.
- W2155803301 hasLocation W21558033011 @default.
- W2155803301 hasLocation W21558033012 @default.
- W2155803301 hasOpenAccess W2155803301 @default.
- W2155803301 hasPrimaryLocation W21558033011 @default.
- W2155803301 hasRelatedWork W1818826284 @default.
- W2155803301 hasRelatedWork W1996372475 @default.
- W2155803301 hasRelatedWork W2019340165 @default.
- W2155803301 hasRelatedWork W2028329711 @default.
- W2155803301 hasRelatedWork W2046438699 @default.
- W2155803301 hasRelatedWork W2073543802 @default.
- W2155803301 hasRelatedWork W2169738785 @default.
- W2155803301 hasRelatedWork W2410629643 @default.
- W2155803301 hasRelatedWork W2415752537 @default.
- W2155803301 hasRelatedWork W2803198186 @default.
- W2155803301 hasVolume "30" @default.
- W2155803301 isParatext "false" @default.
- W2155803301 isRetracted "false" @default.
- W2155803301 magId "2155803301" @default.
- W2155803301 workType "article" @default.