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- W2155805441 abstract "Effective immunotherapy for cancer depends on cellular responses to tumor antigens. The role of major histocompatibility complex (MHC) in T-cell recognition and T-cell receptor repertoire selection has become a central tenet in immunology. Structurally, this does not contradict earlier findings that T-cells can differentiate between small hapten structures like simple glycans. Understanding T-cell recognition of antigens as defined genetically by MHC and combinatorially by T cell receptors led to the altered self hypothesis. This notion reflects a more fundamental principle underlying immune surveillance and integrating evolutionarily and mechanistically diverse elements of the immune system. Danger associated molecular patterns, including those generated by glycan remodeling, represent an instance of altered self. A prominent example is the modification of the tumor-associated antigen MUC1. Similar examples emphasize glycan reactivity patterns of antigen receptors as a phenomenon bridging innate and adaptive but also humoral and cellular immunity and providing templates for immunotherapies." @default.
- W2155805441 created "2016-06-24" @default.
- W2155805441 creator A5020464539 @default.
- W2155805441 creator A5051938893 @default.
- W2155805441 creator A5059945874 @default.
- W2155805441 creator A5070854164 @default.
- W2155805441 date "2010-01-01" @default.
- W2155805441 modified "2023-10-14" @default.
- W2155805441 title "Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans" @default.
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