FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155808168> ?p ?o ?g. }

• W2155808168 endingPage "7" @default.
• W2155808168 startingPage "7" @default.
• W2155808168 abstract "It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apoptosis seem to be contradictory. Interestingly, both abilities have been widely reported in the literature for the HTLV-I Tax protein. To reconcile these apparently divergent findings, we sought to understand how Tax might cause apoptosis in a Jurkat T-cell line, JPX-9. Tax expression can be induced equally by either cadmium (Cd) or zinc (Zn) in JPX-9 cells. Surprisingly, when induced by Zn, but not when induced by Cd, Tax-expression produced significant apoptosis. Under our experimental conditions, Zn but not Cd, induced SAPK (stress activated protein kinase)/JNK (Jun kinase) activation in cells. We further showed that transient over-expression of Tax-alone or Jun-alone did not induce cell death. On the other hand, co-expression of Tax plus Jun did effectively result in apoptosis. We propose that Tax-expression alone in a T-cell background insufficiently accounts for apoptosis. On the other hand, Tax plus activation of a stress kinase can induce cell death. Thus, HTLV-I infection/transformation of cells requires two discrete events (i.e. oncoprotein expression and stress) to produce apoptosis." @default.
• W2155808168 created "2016-06-24" @default.
• W2155808168 creator A5067284412 @default.
• W2155808168 creator A5080524336 @default.
• W2155808168 date "2004-01-01" @default.
• W2155808168 modified "2023-09-25" @default.
• W2155808168 cites W108235626 @default.
• W2155808168 cites W1483473129 @default.
• W2155808168 cites W1502806819 @default.
• W2155808168 cites W1559919026 @default.
• W2155808168 cites W1602356478 @default.
• W2155808168 cites W1622349285 @default.
• W2155808168 cites W1659625814 @default.
• W2155808168 cites W1697605735 @default.
• W2155808168 cites W1909840277 @default.
• W2155808168 cites W1945304257 @default.
• W2155808168 cites W1969158591 @default.
• W2155808168 cites W1972442265 @default.
• W2155808168 cites W1975884417 @default.
• W2155808168 cites W1979695251 @default.
• W2155808168 cites W1984159955 @default.
• W2155808168 cites W1985363326 @default.
• W2155808168 cites W1989715180 @default.
• W2155808168 cites W1999754551 @default.
• W2155808168 cites W2000352412 @default.
• W2155808168 cites W2009117316 @default.
• W2155808168 cites W2010298858 @default.
• W2155808168 cites W2021413266 @default.
• W2155808168 cites W2022142379 @default.
• W2155808168 cites W2024949533 @default.
• W2155808168 cites W2029525607 @default.
• W2155808168 cites W2039739465 @default.
• W2155808168 cites W2040642461 @default.
• W2155808168 cites W2041117621 @default.
• W2155808168 cites W2047330178 @default.
• W2155808168 cites W2049873418 @default.
• W2155808168 cites W2051515686 @default.
• W2155808168 cites W2052122913 @default.
• W2155808168 cites W2054902510 @default.
• W2155808168 cites W2058303120 @default.
• W2155808168 cites W2058876735 @default.
• W2155808168 cites W2065392301 @default.
• W2155808168 cites W2074169536 @default.
• W2155808168 cites W2081948388 @default.
• W2155808168 cites W2084208233 @default.
• W2155808168 cites W2095022409 @default.
• W2155808168 cites W2100623645 @default.
• W2155808168 cites W2108898424 @default.
• W2155808168 cites W2114892138 @default.
• W2155808168 cites W2119079908 @default.
• W2155808168 cites W2119116036 @default.
• W2155808168 cites W2119807130 @default.
• W2155808168 cites W2122931119 @default.
• W2155808168 cites W2123147198 @default.
• W2155808168 cites W2124761766 @default.
• W2155808168 cites W2126245351 @default.
• W2155808168 cites W2132625535 @default.
• W2155808168 cites W2139366028 @default.
• W2155808168 cites W2139928557 @default.
• W2155808168 cites W2146419650 @default.
• W2155808168 cites W2148061274 @default.
• W2155808168 cites W2149213229 @default.
• W2155808168 cites W2149511417 @default.
• W2155808168 cites W2171789198 @default.
• W2155808168 cites W2321042619 @default.
• W2155808168 cites W2339374716 @default.
• W2155808168 cites W2438433439 @default.
• W2155808168 cites W7405620 @default.
• W2155808168 doi "https://doi.org/10.1186/1742-4690-1-7" @default.
• W2155808168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/419724" @default.
• W2155808168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15169569" @default.
• W2155808168 hasPublicationYear "2004" @default.
• W2155808168 type Work @default.
• W2155808168 sameAs 2155808168 @default.
• W2155808168 citedByCount "29" @default.
• W2155808168 countsByYear W21558081682012 @default.
• W2155808168 countsByYear W21558081682013 @default.
• W2155808168 countsByYear W21558081682014 @default.
• W2155808168 countsByYear W21558081682015 @default.
• W2155808168 crossrefType "journal-article" @default.
• W2155808168 hasAuthorship W2155808168A5067284412 @default.
• W2155808168 hasAuthorship W2155808168A5080524336 @default.
• W2155808168 hasBestOaLocation W21558081681 @default.
• W2155808168 hasConcept C1491633281 @default.
• W2155808168 hasConcept C179464577 @default.
• W2155808168 hasConcept C184235292 @default.
• W2155808168 hasConcept C190283241 @default.
• W2155808168 hasConcept C203014093 @default.
• W2155808168 hasConcept C2776090121 @default.
• W2155808168 hasConcept C31573885 @default.
• W2155808168 hasConcept C502942594 @default.
• W2155808168 hasConcept C54355233 @default.
• W2155808168 hasConcept C55493867 @default.
• W2155808168 hasConcept C81885089 @default.
• W2155808168 hasConcept C86803240 @default.
• W2155808168 hasConcept C8891405 @default.
• W2155808168 hasConcept C95444343 @default.
• W2155808168 hasConcept C97029542 @default.

• next