FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155859877> ?p ?o ?g. }

• W2155859877 endingPage "1061" @default.
• W2155859877 startingPage "1049" @default.
• W2155859877 abstract "Abstract Tissue infiltration of macrophages, although critical for innate immunity, is also involved in pathologies, such as chronic inflammation and cancer. In vivo, macrophages migrate mostly in a constrained three-dimensional (3D) environment. However, in vitro studies, mainly focused on two dimensions, do not provide meaningful clues about the mechanisms involved in 3D macrophage migration. In contrast, tumor cell 3D migration is well documented. It comprises a protease-independent and Rho kinase (ROCK)-dependent amoeboid migration mode and a protease-dependent and ROCK-independent mesenchymal migration mode. In this study, we examined the influence of extracellular matrix (composition, architecture, and stiffness) on 3D migration of human macrophages derived from blood monocytes (MDMs). We show that: 1) MDMs use either the amoeboid migration mode in fibrillar collagen I or the mesenchymal migration mode in Matrigel and gelled collagen I, whereas HT1080 tumor cells only perform mesenchymal migration; 2) when MDMs use the mesenchymal migratory mode, they form 3D collagenolytic structures at the tips of cell protrusions that share several markers with podosomes as described in two dimensions; 3) in contrast to tumor cells, matrix metalloproteinase inhibitors do not impair protease-dependent macrophage 3D migration, suggesting the involvement of other proteolytic systems; and 4) MDMs infiltrating matrices of similar composition but with variable stiffness adapt their migration mode primarily to the matrix architecture. In conclusion, although it is admitted that leukocytes 3D migration is restricted to the amoeboid mode, we show that human macrophages also perform the mesenchymal mode but in a distinct manner than tumor cells, and they naturally adapt their migration mode to the environmental constraints." @default.
• W2155859877 created "2016-06-24" @default.
• W2155859877 creator A5019109769 @default.
• W2155859877 creator A5024675355 @default.
• W2155859877 creator A5042001540 @default.
• W2155859877 creator A5065462013 @default.
• W2155859877 creator A5028484341 @default.
• W2155859877 date "2009-12-27" @default.
• W2155859877 modified "2023-10-14" @default.
• W2155859877 title "Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures" @default.
• W2155859877 cites W1503696655 @default.
• W2155859877 cites W1808025966 @default.
• W2155859877 cites W1901579144 @default.
• W2155859877 cites W1967470122 @default.
• W2155859877 cites W1968416941 @default.
• W2155859877 cites W1968783143 @default.
• W2155859877 cites W1973568716 @default.
• W2155859877 cites W1974055700 @default.
• W2155859877 cites W1980488526 @default.
• W2155859877 cites W1980845037 @default.
• W2155859877 cites W1980900741 @default.
• W2155859877 cites W1984283577 @default.
• W2155859877 cites W1986411839 @default.
• W2155859877 cites W1991370659 @default.
• W2155859877 cites W1992218898 @default.
• W2155859877 cites W1993006648 @default.
• W2155859877 cites W1997073288 @default.
• W2155859877 cites W1999251467 @default.
• W2155859877 cites W2003074738 @default.
• W2155859877 cites W2009050428 @default.
• W2155859877 cites W2012775486 @default.
• W2155859877 cites W2021673391 @default.
• W2155859877 cites W2022363275 @default.
• W2155859877 cites W2023339355 @default.
• W2155859877 cites W2024137212 @default.
• W2155859877 cites W2026632078 @default.
• W2155859877 cites W2028951998 @default.
• W2155859877 cites W2029351072 @default.
• W2155859877 cites W2030582971 @default.
• W2155859877 cites W2032494769 @default.
• W2155859877 cites W2034656098 @default.
• W2155859877 cites W2035538295 @default.
• W2155859877 cites W2035809865 @default.
• W2155859877 cites W2043436438 @default.
• W2155859877 cites W2043689428 @default.
• W2155859877 cites W2044491736 @default.
• W2155859877 cites W2054635074 @default.
• W2155859877 cites W2059654418 @default.
• W2155859877 cites W2060537876 @default.
• W2155859877 cites W2065017228 @default.
• W2155859877 cites W2069271306 @default.
• W2155859877 cites W2076782790 @default.
• W2155859877 cites W2080667388 @default.
• W2155859877 cites W2080860848 @default.
• W2155859877 cites W2082103058 @default.
• W2155859877 cites W2083543572 @default.
• W2155859877 cites W2094589757 @default.
• W2155859877 cites W2099675490 @default.
• W2155859877 cites W2110602562 @default.
• W2155859877 cites W2111711361 @default.
• W2155859877 cites W2124045232 @default.
• W2155859877 cites W2129926378 @default.
• W2155859877 cites W2133569303 @default.
• W2155859877 cites W2138833446 @default.
• W2155859877 cites W2139196708 @default.
• W2155859877 cites W2141089307 @default.
• W2155859877 cites W2143460256 @default.
• W2155859877 cites W2147336841 @default.
• W2155859877 cites W2148501741 @default.
• W2155859877 cites W2166566864 @default.
• W2155859877 cites W2168116130 @default.
• W2155859877 cites W2170770186 @default.
• W2155859877 cites W2317145780 @default.
• W2155859877 cites W2803499602 @default.
• W2155859877 cites W74202404 @default.
• W2155859877 doi "https://doi.org/10.4049/jimmunol.0902223" @default.
• W2155859877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20018633" @default.
• W2155859877 hasPublicationYear "2009" @default.
• W2155859877 type Work @default.
• W2155859877 sameAs 2155859877 @default.
• W2155859877 citedByCount "294" @default.
• W2155859877 countsByYear W21558598772012 @default.
• W2155859877 countsByYear W21558598772013 @default.
• W2155859877 countsByYear W21558598772014 @default.
• W2155859877 countsByYear W21558598772015 @default.
• W2155859877 countsByYear W21558598772016 @default.
• W2155859877 countsByYear W21558598772017 @default.
• W2155859877 countsByYear W21558598772018 @default.
• W2155859877 countsByYear W21558598772019 @default.
• W2155859877 countsByYear W21558598772020 @default.
• W2155859877 countsByYear W21558598772021 @default.
• W2155859877 countsByYear W21558598772022 @default.
• W2155859877 countsByYear W21558598772023 @default.
• W2155859877 crossrefType "journal-article" @default.
• W2155859877 hasAuthorship W2155859877A5019109769 @default.
• W2155859877 hasAuthorship W2155859877A5024675355 @default.
• W2155859877 hasAuthorship W2155859877A5028484341 @default.
• W2155859877 hasAuthorship W2155859877A5042001540 @default.

• next