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- W2155861639 abstract "Two patients affected by cancer in the advanced phase and suffering umbereable pain received the simultaneous administration of a pure hydrophilic mu agonist (morphine) and a lipophilic partial mu agonist (buprenorphine). Morphine was administered intrathecally, buprenorphine intravenously in both cases.This report demonstrates that the administration of small doses of intrathecal morphine to patients receiving intravenous buprenorphine and vice versa does not produce a decrease in the level of analgesia. The simultaneous administration of the two drugs produced a deep and sustained pain relief; this fact seems surprizing since one would expect the contrary. It is accepted that the combined and simultaneous administration of a pure mu agonist together with a partial mu agonist leads to a decrease in the level of pain relief.However, the clinical evidence has demonstrated that the simultaneous administration of intrathecal morphine with intravenous buprenorphine produced better pain control and a lesser incidence of side-effects. Further studies in humans are needed." @default.
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- W2155861639 date "2000-06-01" @default.
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- W2155861639 title "Pain relief after simultaneous administration of intravenous buprenorphine and intrathecal morphine in terminally ill patients; A report of two cases" @default.
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- W2155861639 doi "https://doi.org/10.1163/156856900750229889" @default.
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