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• W2155883106 abstract "Purpose To develop a silicon (Si) and cadmium telluride (CdTe) imaging Compton camera for biomedical application on the basis of technologies used for astrophysical observation and to test its capacity to perform three-dimensional (3D) imaging. Materials and Methods All animal experiments were performed according to the Animal Care and Experimentation Committee (Gunma University, Maebashi, Japan). Flourine 18 fluorodeoxyglucose (FDG), iodine 131 (131I) methylnorcholestenol, and gallium 67 (67Ga) citrate, separately compacted into micro tubes, were inserted subcutaneously into a Wistar rat, and the distribution of the radioisotope compounds was determined with 3D imaging by using the Compton camera after the rat was sacrificed (ex vivo model). In a separate experiment, indium 111(111In) chloride and 131I-methylnorcholestenol were injected into a rat intravenously, and copper 64 (64Cu) chloride was administered into the stomach orally just before imaging. The isotope distributions were determined with 3D imaging after sacrifice by means of the list-mode-expectation-maximizing-maximum-likelihood method. Results The Si/CdTe Compton camera demonstrated its 3D multinuclear imaging capability by separating out the distributions of FDG, 131I-methylnorcholestenol, and 67Ga-citrate clearly in a test-tube–implanted ex vivo model. In the more physiologic model with tail vein injection prior to sacrifice, the distributions of 131I-methylnorcholestenol and 64Cu-chloride were demonstrated with 3D imaging, and the difference in distribution of the two isotopes was successfully imaged although the accumulation on the image of 111In-chloride was difficult to visualize because of blurring at the low-energy region. Conclusion The Si/CdTe Compton camera clearly resolved the distribution of multiple isotopes in 3D imaging and simultaneously in the ex vivo model. © RSNA, 2013" @default.
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• W2155883106 date "2013-06-01" @default.
• W2155883106 modified "2023-10-17" @default.
• W2155883106 title "Three-dimensional and Multienergy Gamma-ray Simultaneous Imaging by Using a Si/CdTe Compton Camera" @default.
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• W2155883106 doi "https://doi.org/10.1148/radiol.13121194" @default.
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