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• W2155924591 abstract "Tick-borne encephalitis virus (TBEV) is a zoonotic disease agent that causes severe encephalitis in humans. The envelope protein E of TBEV has one N -linked glycosylation consensus sequence, but little is known about the biological function of the N -linked glycan. In this study, the function of protein E glycosylation was investigated using recombinant TBEV with or without the protein E N -linked glycan. Virion infectivity was not affected after removing the N -linked glycans using N -glycosidase F. In mammalian cells, loss of glycosylation affected the conformation of protein E during secretion, reducing the infectivity of secreted virions. Mice subcutaneously infected with TBEV lacking protein E glycosylation showed no signs of disease, and viral multiplication in peripheral organs was reduced relative to that with the parental virus. In contrast, loss of glycosylation did not affect the secretory process of infectious virions in tick cells. Furthermore, inhibition of transport to the Golgi apparatus affected TBEV secretion in mammalian cells, but not in tick cells, indicating that TBEV was secreted through an unidentified pathway after synthesis in endoplasmic reticulum in tick cells. These results increase our understanding of the molecular mechanisms of TBEV maturation." @default.
• W2155924591 created "2016-06-24" @default.
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• W2155924591 creator A5054301438 @default.
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• W2155924591 date "2013-10-01" @default.
• W2155924591 modified "2023-10-16" @default.
• W2155924591 title "N-linked glycan in tick-borne encephalitis virus envelope protein affects viral secretion in mammalian cells, but not in tick cells" @default.
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• W2155924591 doi "https://doi.org/10.1099/vir.0.055269-0" @default.
• W2155924591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23824303" @default.
• W2155924591 hasPublicationYear "2013" @default.
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