FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155940448> ?p ?o ?g. }

• W2155940448 endingPage "1589" @default.
• W2155940448 startingPage "1581" @default.
• W2155940448 abstract "Acute graft-versus-host disease (GVHD) and leukemic relapse remain the two major obstacles to successful outcomes after allogeneic bone marrow transplantation (BMT). Recent studies have demonstrated that the loss of gastrointestinal tract integrity, and specifically the translocation of LPS into the systemic circulation, is critical to the induction of cytokine dysregulation that contributes to GVHD. Using a mouse BMT model, we studied the effects of direct LPS antagonism on GVHD severity and graft-versus-leukemia (GVL) activity. Administration of B975, a synthetic lipid-A analogue from day 0 to day +6, reduced serum TNF-alpha levels, decreased intestinal histopathology, and resulted in significantly improved survival and a reduction in clinical GVHD, compared with control-treated animals. Importantly, B975 had no effect on donor T cell responses to host antigens in vivo or in vitro. When mice received lethal doses of P815 tumor cells at the time of BMT, administration of B975 did not impair GVL activity and resulted in significantly improved leukemia-free survival. These findings reveal a critical role for LPS in the early inflammatory events contributing to GVHD and suggest that a new class of pharmacologic agents, LPS antagonists, may help to prevent GVHD while preserving T cell responses to host antigens and GVL activity." @default.
• W2155940448 created "2016-06-24" @default.
• W2155940448 creator A5005615409 @default.
• W2155940448 creator A5007506005 @default.
• W2155940448 creator A5023099227 @default.
• W2155940448 creator A5040158605 @default.
• W2155940448 creator A5040159118 @default.
• W2155940448 creator A5041455800 @default.
• W2155940448 creator A5053083873 @default.
• W2155940448 creator A5068048596 @default.
• W2155940448 date "2001-06-15" @default.
• W2155940448 modified "2023-10-15" @default.
• W2155940448 title "LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation" @default.
• W2155940448 cites W116285681 @default.
• W2155940448 cites W1274344746 @default.
• W2155940448 cites W138896090 @default.
• W2155940448 cites W1502521547 @default.
• W2155940448 cites W1526571057 @default.
• W2155940448 cites W1542075228 @default.
• W2155940448 cites W1544331058 @default.
• W2155940448 cites W1544569979 @default.
• W2155940448 cites W1557444833 @default.
• W2155940448 cites W156080801 @default.
• W2155940448 cites W1608695296 @default.
• W2155940448 cites W175560591 @default.
• W2155940448 cites W1795844187 @default.
• W2155940448 cites W1831744086 @default.
• W2155940448 cites W1902759499 @default.
• W2155940448 cites W1909810986 @default.
• W2155940448 cites W1918787965 @default.
• W2155940448 cites W1937497148 @default.
• W2155940448 cites W1982197503 @default.
• W2155940448 cites W2004312195 @default.
• W2155940448 cites W2008077535 @default.
• W2155940448 cites W2025082986 @default.
• W2155940448 cites W2035649755 @default.
• W2155940448 cites W2036334656 @default.
• W2155940448 cites W2064411005 @default.
• W2155940448 cites W2068145342 @default.
• W2155940448 cites W2071927386 @default.
• W2155940448 cites W20746832 @default.
• W2155940448 cites W2078514942 @default.
• W2155940448 cites W2079408154 @default.
• W2155940448 cites W2087521550 @default.
• W2155940448 cites W2093452703 @default.
• W2155940448 cites W2094292853 @default.
• W2155940448 cites W2109168421 @default.
• W2155940448 cites W2116912813 @default.
• W2155940448 cites W2120428769 @default.
• W2155940448 cites W2154101238 @default.
• W2155940448 cites W2173272774 @default.
• W2155940448 cites W2173789706 @default.
• W2155940448 cites W2211849351 @default.
• W2155940448 cites W2279252100 @default.
• W2155940448 cites W2303086609 @default.
• W2155940448 cites W2327441947 @default.
• W2155940448 cites W2339483125 @default.
• W2155940448 cites W2401388802 @default.
• W2155940448 cites W2411358376 @default.
• W2155940448 cites W2412572117 @default.
• W2155940448 cites W2417058604 @default.
• W2155940448 cites W2460462963 @default.
• W2155940448 cites W2461837629 @default.
• W2155940448 cites W61041017 @default.
• W2155940448 doi "https://doi.org/10.1172/jci12156" @default.
• W2155940448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/200193" @default.
• W2155940448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11413166" @default.
• W2155940448 hasPublicationYear "2001" @default.
• W2155940448 type Work @default.
• W2155940448 sameAs 2155940448 @default.
• W2155940448 citedByCount "273" @default.
• W2155940448 countsByYear W21559404482012 @default.
• W2155940448 countsByYear W21559404482013 @default.
• W2155940448 countsByYear W21559404482014 @default.
• W2155940448 countsByYear W21559404482015 @default.
• W2155940448 countsByYear W21559404482016 @default.
• W2155940448 countsByYear W21559404482017 @default.
• W2155940448 countsByYear W21559404482018 @default.
• W2155940448 countsByYear W21559404482019 @default.
• W2155940448 countsByYear W21559404482020 @default.
• W2155940448 countsByYear W21559404482021 @default.
• W2155940448 countsByYear W21559404482022 @default.
• W2155940448 countsByYear W21559404482023 @default.
• W2155940448 crossrefType "journal-article" @default.
• W2155940448 hasAuthorship W2155940448A5005615409 @default.
• W2155940448 hasAuthorship W2155940448A5007506005 @default.
• W2155940448 hasAuthorship W2155940448A5023099227 @default.
• W2155940448 hasAuthorship W2155940448A5040158605 @default.
• W2155940448 hasAuthorship W2155940448A5040159118 @default.
• W2155940448 hasAuthorship W2155940448A5041455800 @default.
• W2155940448 hasAuthorship W2155940448A5053083873 @default.
• W2155940448 hasAuthorship W2155940448A5068048596 @default.
• W2155940448 hasBestOaLocation W21559404481 @default.
• W2155940448 hasConcept C126322002 @default.
• W2155940448 hasConcept C150903083 @default.
• W2155940448 hasConcept C203014093 @default.
• W2155940448 hasConcept C207001950 @default.
• W2155940448 hasConcept C2776090121 @default.

• next