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• W2155952912 abstract "Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are overlapping neurodegenerative disorders. Mutations in the growth factor progranulin (PGRN) gene cause FTLD, sometimes in conjunction with ALS; such mutations are also observed in some ALS patients. Most PGRN mutations underlying FTLD are null mutations that result in reduced PGRN levels. We investigated PGRN expression in human ALS and in mouse models of motor neuron degeneration. Progranulin plasma or CSF levels in newly diagnosed ALS patients did not differ from those in healthy or disease controls (PGRN mutation-negative FTLD and Alzheimer disease patients). In the mutant SOD1G93A mouse model of ALS, spinal cord PGRN levels were normal in presymptomatic animals but increased during the degenerative process. This increase in PGRN correlated with enhanced expression of PGRN in microglia. In CSF, PGRN levels were normal in presymptomatic and early symptomatic animals, but with disease progression, a raise in PGRN was detectable. These data indicate that upregulation of PGRN is a marker of the microglial response that occurs with progression in motor neuron diseases." @default.
• W2155952912 created "2016-06-24" @default.
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• W2155952912 date "2010-12-01" @default.
• W2155952912 modified "2023-10-18" @default.
• W2155952912 title "Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration" @default.
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• W2155952912 doi "https://doi.org/10.1097/nen.0b013e3181fc9aea" @default.
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• W2155952912 hasPublicationYear "2010" @default.
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