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- W2155963414 abstract "We calibrated a scintillation camera for the counts-to-activity conversion factor, CF, by measuring a phantom consisting of a sphere containing a known 131-I activity placed within an elliptical cylinder. Within a 3D OSEM reconstruction algorithm, we employed a depth-dependent detector-response model based on smooth fits to the point-source-response function. Using the ultra-high-energy (UHE) collimator and 100 iterations, the recovery coefficient, RC, appeared to be 1 for any sphere volume down to 20 cm/sup 3/. The CF changed only a small amount as the background-over-target activity concentration ratio, b, increased for both UHE and high-energy (HE) collimation. Tests of activity quantification were carried out with an anthropomorphic phantom simulating a 100 cm/sup 3/ spherical tumor centrally located inferior to the lungs. With 3D OSEM reconstruction, using the global-average CF and no RC-based correction, mean bias in the simulated-tumor activity estimate over 20 realizations was -7.4% with UHE collimation, and -9.4% with HE collimation. For comparison, with 1D SAGE reconstruction, using the CF corresponding to the experimental estimate of b and RC-based correction, the mean bias was worse, -10.7% for UHE collimation, but better, -4.3 %, for HE collimation." @default.
- W2155963414 created "2016-06-24" @default.
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- W2155963414 date "2004-11-30" @default.
- W2155963414 modified "2023-09-23" @default.
- W2155963414 title "Update on HE vs UHE collimation for focal total-activity quantification in I-131 SPECT using 3D OSEM" @default.
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- W2155963414 doi "https://doi.org/10.1109/nssmic.2003.1352492" @default.
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