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• W2155990587 abstract "Either testosterone or follicle-stimulating hormone (FSH) stimulates progesterone secretion by granulosa cells from rats but the combination of the two hormones increases progesterone production in a synergistic manner. We have investigated the effects of graded doses of prolactin (0, 0.02, 0.2, 2, or 10 μg/ml) alone or in combination with testosterone (0.5 μM), FSH (300 ng/ml), or FSH + testosterone on progesterone secretion by granulosa cells at two stages of differentiation. Relatively undifferentiated granulosa cells from immature, diethylstilbestrol-treated, hypophysectomized (HPX) rats were cultured in defined (serum-free) medium for 3 days. More highly differentiated granulosa cells were obtained on the morning of proestrus from the preovulatory follicles of 30-day-old rats induced to undergo an estrous cycle by injection with 4 IU pregnant mare’s serum gonadotropin; these cells were cultured in medium containing 10% fetal bovine serum. Prolactin alone did not enhance the negligible secretion of progesterone by cells from HPX rats, but increased progesterone secretion by cells from proestrous rats. Prolactin significantly enhanced the stimulatory effects of testosterone or FSH alone on cells from both HPX and proestrous rats. When cultures containing both FSH + testosterone were treated with prolactin, progesterone secretion by cells from proestrous rats was significantly enhanced, whereas secretion by cells from HPX rats was significantly depressed. Therefore when cells from HPX rats were cultured with both FSH and testosterone, the direction of the effect of prolactin was reversed from that observed with prolactin + FSH or testosterone alone, and from that observed when cells from proestrous rats were cultured with prolactin + FSH + testosterone. To determine whether the difference in results for the two models was due to differences in the stage of differentiation of the granulosa cells or to the different culture systems, the experiments were repeated with cells from HPX rats and with medium containing 10% serum, With these culture conditions prolactin stimulated progesterone secretion when used alone or in combination with FSH, testosterone, or FSH + testosterone. In summary, prolactin in general stimulated secretion of progesterone by both undifferentiated and relatively differentiated granulosa cells from rats and enhanced the stimulatory effects of FSH, testosterone, and FSH + testosterone; however, its enhancement of the effect of FSH + testosterone could be reversed by removing serum from the medium." @default.
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• W2155990587 date "1986-08-01" @default.
• W2155990587 modified "2023-10-17" @default.
• W2155990587 title "Prolactin Modulates Steroidogenesis by Rat Granulosa Cells: I. Effects on Progesterone1" @default.
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• W2155990587 doi "https://doi.org/10.1095/biolreprod35.1.84" @default.
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