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- W2155990667 abstract "Background. Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD); however, the mechanisms are poorly understood. The endothelin system exhibits potent pro-fibrotic properties and is known to be stimulated in peritoneal fibrosis. Thus, our study aimed at elucidating the impact of the endothelin B (ETB) receptor on peritoneal membrane thickening by means of an ETB-deficient rat model (ETB−/−) in experimental PD. Methods. Wild-type (WT) and ETB−/− rats were randomly allocated to four groups (each group n = 10): (i) WT Sham, (ii) WT PD, (iii) ETB−/− Sham and (iv) ETB−/− PD. All animals underwent surgical implantation of a port for intraperitoneal administration and 1 week of habituation to the procedure by administration of 2 ml of saline once daily. Afterwards, all animals were switched to 12 weeks of 15 ml of saline (Sham groups) or commercially available PD fluid containing 3.86% glucose (PD groups) administered twice daily. Afterwards, animals were sacrificed, and samples from visceral as well as parietal peritoneum were obtained. The samples were stained with Sirius-Red, and at 10 different sites per sample, peritoneal membrane thickness was measured using computer-aided histomorphometry devices. Results. Mean peritoneal membrane thickness was increased by PD in both WT and ETB−/− rats versus respective Sham controls (WT Sham: 22.3 ± 0.7 µm/ETB Sham: 22.3 ± 0.9 µm versus WT PD: 26.5 ± 1.5 µm/ETB PD: 28.7 ± 1.2 µm; P < 0.05, respectively). However, no difference in peritoneal membrane thickness was detected between WT PD and ETB−/− PD groups. Conclusion. Our study demonstrates that PD increases peritoneal membrane thickness in a rat model, but deficiency of the ETB receptor has no detectable impact on this process." @default.
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- W2155990667 date "2009-11-26" @default.
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- W2155990667 title "Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis?" @default.
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- W2155990667 doi "https://doi.org/10.1093/ndt/gfp652" @default.
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