Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155993357> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2155993357 endingPage "461" @default.
- W2155993357 startingPage "457" @default.
- W2155993357 abstract "Rheumatic fever is still the leading cause of acquired heart disease in children and young adults in developing countries. Recent reports have documented a rising incidence of rheumatic fever in both the USA and Europe. The disease is characterized by specific lesions in the heart muscle and valves called Aschoff nodules. The Aschoff nodule has been neglected in the last few decades as most of the studies were conducted in the 1960s on autopsy tissues. This study examines Aschoff nodules using heart valve material obtained at valve surgery with updated commercially available immunohistochemical antibodies to determine the phenotypic characteristics of the cells involved in the formation of these lesions. Fifteen cases of rheumatic valvulitis, as indicated by the presence of Aschoff nodules, were examined. The Anitschkow and Aschoff cells stained prominently with macrophage markers. Three stages of nodules with Aschoff and Anitschkow cells were identified: stage 1, central fibrinoid necrosis without lymphocytes, stage 2 with occasional T lymphocytes (< 10) and stage 3 with lymphoid aggregates containing both T- and B-lymphocytes (with occasional admixed macrophages). We propose that the stage 1 lesion is the earliest granulomatous stage with the lymphoid aggregates being a later stage in the development of Aschoff nodules. The Aschoff and Anitschkow cells demonstrated mitotic activity and stained with antibodies to the proliferation cell nuclear antigen (PCNA) suggesting that the multinucleated giant cells may be formed, at least partially, by nuclear division rather than fusion." @default.
- W2155993357 created "2016-06-24" @default.
- W2155993357 creator A5045235776 @default.
- W2155993357 creator A5050361667 @default.
- W2155993357 creator A5058127971 @default.
- W2155993357 date "1995-11-01" @default.
- W2155993357 modified "2023-10-16" @default.
- W2155993357 title "Rheumatic Aschoff nodules revisited: an immunohistological reappraisal of the cellular component" @default.
- W2155993357 cites W1989714149 @default.
- W2155993357 cites W2007060791 @default.
- W2155993357 cites W2034234514 @default.
- W2155993357 cites W2053717292 @default.
- W2155993357 cites W2059905029 @default.
- W2155993357 cites W2062426795 @default.
- W2155993357 cites W2068239135 @default.
- W2155993357 cites W2079016503 @default.
- W2155993357 cites W2093157102 @default.
- W2155993357 cites W2323252911 @default.
- W2155993357 doi "https://doi.org/10.1111/j.1365-2559.1995.tb00310.x" @default.
- W2155993357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8575737" @default.
- W2155993357 hasPublicationYear "1995" @default.
- W2155993357 type Work @default.
- W2155993357 sameAs 2155993357 @default.
- W2155993357 citedByCount "22" @default.
- W2155993357 countsByYear W21559933572013 @default.
- W2155993357 countsByYear W21559933572015 @default.
- W2155993357 countsByYear W21559933572016 @default.
- W2155993357 countsByYear W21559933572017 @default.
- W2155993357 countsByYear W21559933572018 @default.
- W2155993357 countsByYear W21559933572019 @default.
- W2155993357 countsByYear W21559933572022 @default.
- W2155993357 countsByYear W21559933572023 @default.
- W2155993357 crossrefType "journal-article" @default.
- W2155993357 hasAuthorship W2155993357A5045235776 @default.
- W2155993357 hasAuthorship W2155993357A5050361667 @default.
- W2155993357 hasAuthorship W2155993357A5058127971 @default.
- W2155993357 hasConcept C142724271 @default.
- W2155993357 hasConcept C151730666 @default.
- W2155993357 hasConcept C2776731575 @default.
- W2155993357 hasConcept C2779504383 @default.
- W2155993357 hasConcept C71924100 @default.
- W2155993357 hasConcept C77076574 @default.
- W2155993357 hasConcept C86803240 @default.
- W2155993357 hasConceptScore W2155993357C142724271 @default.
- W2155993357 hasConceptScore W2155993357C151730666 @default.
- W2155993357 hasConceptScore W2155993357C2776731575 @default.
- W2155993357 hasConceptScore W2155993357C2779504383 @default.
- W2155993357 hasConceptScore W2155993357C71924100 @default.
- W2155993357 hasConceptScore W2155993357C77076574 @default.
- W2155993357 hasConceptScore W2155993357C86803240 @default.
- W2155993357 hasIssue "5" @default.
- W2155993357 hasLocation W21559933571 @default.
- W2155993357 hasLocation W21559933572 @default.
- W2155993357 hasOpenAccess W2155993357 @default.
- W2155993357 hasPrimaryLocation W21559933571 @default.
- W2155993357 hasRelatedWork W1931629770 @default.
- W2155993357 hasRelatedWork W1999301498 @default.
- W2155993357 hasRelatedWork W2013743956 @default.
- W2155993357 hasRelatedWork W2059773962 @default.
- W2155993357 hasRelatedWork W2077116896 @default.
- W2155993357 hasRelatedWork W2100567927 @default.
- W2155993357 hasRelatedWork W2187122616 @default.
- W2155993357 hasRelatedWork W2272715730 @default.
- W2155993357 hasRelatedWork W2335198228 @default.
- W2155993357 hasRelatedWork W2467719995 @default.
- W2155993357 hasVolume "27" @default.
- W2155993357 isParatext "false" @default.
- W2155993357 isRetracted "false" @default.
- W2155993357 magId "2155993357" @default.
- W2155993357 workType "article" @default.