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- W2155994411 abstract "Heparin resistance (unresponsiveness to heparin) is characterized by the inability to reach acceptable activated clotting time values following a calculated dose of heparin. Up to 20% of the patients undergoing cardiothoracic surgery with cardiopulmonary bypass using unfractionated heparin (UFH) for anticoagulation experience heparin resistance. Although UFH has been the gold standard for anticoagulation, it is not without its limitations. It is contraindicated in patients with confirmed heparin-induced thrombocytopenia (HIT) and heparin or protamine allergy. The safety and efficacy of the use of the direct thrombin inhibitor bivalirudin for anticoagulation during cardiac surgery has been reported. However, there have been no reports on the treatment of heparin resistance with bivalirudin during CPB. In this review, we report the favorable outcome of our single-center experience with the alternative use of bivalirudin in the management of anticoagulation of heparin unresponsive patients undergoing coronary artery bypass graft surgery." @default.
- W2155994411 created "2016-06-24" @default.
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- W2155994411 creator A5031482090 @default.
- W2155994411 creator A5042479933 @default.
- W2155994411 creator A5066349275 @default.
- W2155994411 date "2015-05-01" @default.
- W2155994411 modified "2023-09-26" @default.
- W2155994411 title "Bivalirudin as an adjunctive anticoagulant to heparin in the treatment of heparin resistance during cardiopulmonary bypass-assisted cardiac surgery" @default.
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- W2155994411 doi "https://doi.org/10.1177/0267659115583525" @default.
- W2155994411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25934498" @default.
- W2155994411 hasPublicationYear "2015" @default.
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