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- W2155997555 abstract "Although induced pluripotent stem cells (iPSCs) hold great promise for customized regenerative medicine, the molecular basis of reprogramming is largely unknown. Overcoming barriers that maintain cell identities is a critical step in the reprogramming of differentiated cells. Since microRNAs (miRNAs) modulate target genes tissue-specifically, we reasoned that distinct mouse embryonic fibroblast (MEF)–enriched miRNAs post-transcriptionally modulate proteins that function as reprogramming barriers. Inhibiting these miRNAs should influence cell signaling to lower those barriers. Here we show that depleting miR-21 and miR-29a enhances reprogramming efficiency in MEFs. We also show that the p53 and ERK1/2 pathways are regulated by miR-21 and miR-29a and function in reprogramming. In addition, we provide the first evidence that c-Myc enhances reprogramming partly by repressing MEF-enriched miRNAs, such as miR-21 and miR-29a. Our results demonstrate the significance of miRNA function in regulating multiple signaling networks involved in iPSC generation. These studies should facilitate development of clinically applicable reprogramming strategies." @default.
- W2155997555 created "2016-06-24" @default.
- W2155997555 creator A5005606848 @default.
- W2155997555 creator A5022854447 @default.
- W2155997555 creator A5053074085 @default.
- W2155997555 date "2011-06-21" @default.
- W2155997555 modified "2023-09-27" @default.
- W2155997555 title "microRNAs modulate iPS cell generation" @default.
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- W2155997555 doi "https://doi.org/10.1261/rna.2664111" @default.
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